P464: PULSE DOSING OF POTENT AND SELECTIVE HETEROBIFUNCTIONAL MDM2 DEGRADER KT-253 DRIVES TUMOR REGRESSION AND DEMONSTRATES DIFFERENTIATED PHARMACOLOGY COMPARED TO P53/MDM2 SMALL MOLECULE INHIBITORS
P464：强效选择性异功能MDM2降解剂KT-253的脉冲给药可驱动肿瘤消退，并显示出与P53/MDM2小分子抑制剂不同的药理学特性
期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-47650-z
Liu, Xin-Yi; Yan, Yi-Zhi; Jiang, An-Jun; He, Wan-Ying; Fang, Ying-Yan; Li, Chao-Hui; Deng, Man-Fei; Tan, Si-Jie; Zeng, Peng; Schalm, Stefanie; Chutake, Yogesh; Breitkopf, Susanne; Mayo, Michele; Dumont, Nancy; Chen, Dapeng; Dixit, Vaishali; Karnik, Rahul; Mcdonald, Alice; Filiatrault, Jessica; Proctor, William; Qi, Frank; Hu, Kan-Nian; Weiss, Matt; Gollerkeri, Ashwin; Sharma, Kirti; D Growney, Joseph; Williams, Juliet
