Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
三肽基肽酶 II 协调中枢神经系统中钙和脂质的稳态，其耗竭会导致雌性小鼠出现早老性痴呆，这是由于钙/脂质稳态失衡诱导 CYP19A1 的自噬降解所致
期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.92571
Zhao Jin, He Chengtong, Fan Xueyu, Wang Lin, Zhao Liao, Liu Hui, Shen Wujun, Jiang Sanwei, Pei Kaixuan, Gao Jingjing, Qi Yawei, Liu Yang, Zhao Junqiang, Zhang Ruiling, Lu Chengbiao, Tong Jia, Huai Jisen
