日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

一种具有抗疟活性的II型人激酶抑制剂可抑制恶性疟原虫蛋白激酶6和血红素的形成。

Flore Nardella ,Tiantian Jiang ,Lushun Wang ,Monica J Bohmer ,Subhoja Chakraborty ,John Okombo ,Jaeson Calla ,Tatiane Macedo Silva ,Samuel Pazicky ,Jianwei Che ,Jin Jeon ,Evie Vincent ,Nonlawat Boonyalai ,Rachael Coyle ,Mairi J Buchanan ,Samuel Schaefer ,Daisy Chen ,Amaan Khan ,Emily Mayville ,Mariana Laureano De Souza ,Mayland Treat ,Jordan Charlton ,Patrick K Tumwebaze ,Seth Tjia ,Lukas Montejo ,Karen Cover ,Philip J Rosenthal ,Roland A Cooper ,Zbynek Bozdech ,Marcus C S Lee ,Ratna Chakrabarti ,Sanjay A Desai ,David A Fidock ,Jinhua Wang ,Nathanael S Gray ,Elizabeth A Winzeler ,Debopam Chakrabarti

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

MET激酶结构域中的激活点突变代表了肺癌和其他恶性肿瘤的一个独特的分子亚群,这些亚群可作为MET抑制剂的靶点。

Federica Pecci #,Seshiru Nakazawa #,Biagio Ricciuti,Guilherme Harada,Jessica K Lee,Joao V Alessi,Adriana Barrichello,Victor R Vaz,Giuseppe Lamberti,Alessandro Di Federico,Malini M Gandhi,Dimitris Gazgalis,William W Feng,Jie Jiang,Simon Baldacci,Marie-Anaïs Locquet,Felix H Gottlieb,Monica F Chen,Elinton Lee,Danielle Haradon,Anna Smokovich,Emma Voligny,Tom Nguyen,Vikas K Goel,Zachary Zimmerman,Sumandeep Atwal,Xinan Wang,Magda Bahcall,Rebecca S Heist,Sumaiya Iqbal,Nishant Gandhi,Andrew Elliott,Ari M Vanderwalde,Patrick C Ma,Balazs Halmos,Stephen V Liu,Jianwei Che,Alexa B Schrock,Alexander Drilon,Pasi A Jänne #,Mark M Awad #

Lactate regulates cell cycle by remodelling the anaphase promoting complex

乳酸通过重塑后期促进复合物来调节细胞周期。

Weihai Liu #,Yun Wang #,Luiz H M Bozi #,Patrick D Fischer #,Mark P Jedrychowski,Haopeng Xiao,Tao Wu,Narek Darabedian,Xiadi He,Evanna L Mills,Nils Burger,Sanghee Shin,Anita Reddy,Hans-Georg Sprenger,Nhien Tran,Sally Winther,Stephen M Hinshaw,Jingnan Shen,Hyuk-Soo Seo,Kijun Song,Andrew Z Xu,Luke Sebastian,Jean J Zhao,Sirano Dhe-Paganon,Jianwei Che,Steven P Gygi,Haribabu Arthanari,Edward T Chouchani

Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

利用共价肌酸激酶抑制剂耗竭肌酸磷酸原能量

Narek Darabedian # ,Wenzhi Ji # ,Mengyang Fan ,Shan Lin ,Hyuk-Soo Seo ,Ekaterina V Vinogradova ,Tomer M Yaron ,Evanna L Mills ,Haopeng Xiao ,Kristine Senkane ,Emily M Huntsman ,Jared L Johnson ,Jianwei Che ,Lewis C Cantley ,Benjamin F Cravatt ,Sirano Dhe-Paganon ,Kimberly Stegmaier ,Tinghu Zhang ,Nathanael S Gray ,Edward T Chouchani

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

基于结构的 Y 型共价 TEAD 抑制剂设计

Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y Kim, Xijun Zhu, Andrew Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Stephen M Hinshaw, Behnam Nabet, Steven M Corsello, Nicholas Kwiatkowski, Jarrod A Marto, Tinghu Zh

Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1

开发一种对 c-Jun N 端蛋白激酶 (JNK) 2/3 具有选择性而非 JNK1 的共价抑制剂

Wenchao Lu ,Yao Liu ,Yang Gao ,Qixiang Geng ,Deepak Gurbani ,Lianbo Li ,Scott B Ficarro ,Cynthia J Meyer ,Dhiraj Sinha ,Inchul You ,Jason Tse ,Zhixiang He ,Wenzhi Ji ,Jianwei Che ,Audrey Y Kim ,Tengteng Yu ,Kenneth Wen ,Kenneth C Anderson ,Jarrod A Marto ,Kenneth D Westover ,Tinghu Zhang ,Nathanael S Gray

Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity

具有体内活性的选择性 FAK 抑制剂和 PROTAC 的开发和表征

Eriko Koide, Mikaela L Mohardt, Zainab M Doctor, Annan Yang, Mingfeng Hao, Katherine A Donovan, Christina C Kuismi, Alissa J Nelson, Kathryn Abell, Mike Aguiar, Jianwei Che, Matthew P Stokes, Tinghu Zhang, Andrew J Aguirre, Eric S Fischer, Nathanael S Gray, Baishan Jiang, Behnam Nabet

Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells

TEAD-YAP 的药理阻断揭示了其在癌细胞中的治疗局限性

Yang Sun #, Lu Hu #, Zhipeng Tao #, Gopala K Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L Cotton, Patricia Greninger, Regina K Egan, Y Tony Ip, Cyril H Benes, Jianwei Che, Junhao Mao, Xu Wu

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

造血过程中ABC转运蛋白表达的差异导致Aurora激酶抑制剂对中性粒细胞产生毒性偏向性作用。

David B Chou # ,Brooke A Furlong # ,Ryan R Posey # ,Christos Kyprianou ,Lucy R O'Sullivan ,Rhiannon David ,Suzanne J Randle ,Urszula M Polanska ,Jon Travers ,Jelena Urosevic ,John N Hutchinson ,Jianwei Che ,Anna M Howley ,Robert P Hasserjian ,Rachelle Prantil-Baun ,Donald E Ingber

Exploring the target scope of KEAP1 E3 ligase-based PROTACs

探索基于 KEAP1 E3 连接酶的 PROTAC 的靶标范围

Guangyan Du, Jie Jiang, Nathaniel J Henning, Nozhat Safaee, Eriko Koide, Radosław P Nowak, Katherine A Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A Eleuteri, Zhixiang He, Zhengnian Li, Hubert T Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S Fischer, Nathanael S Gray