日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hsp90α forms condensate engaging client proteins with RG motif repeats

Hsp90α 形成具有 RG 基序重复的凝聚体结合客户蛋白

Jiaojiao Hu, Hui Dong, Yichen Li, Jinge Gu, Liang Yang, Chenfang Si, Yaoyang Zhang, Tingting Li, Dan Li, Cong Liu

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

热休克分子伴侣 HSPB1 调节细胞质 TDP-43 相分离和液体到凝胶的转变

Shan Lu, Jiaojiao Hu, Olubankole Aladesuyi Arogundade, Alexander Goginashvili, Sonia Vazquez-Sanchez, Jolene K Diedrich, Jinge Gu, Jacob Blum, Spencer Oung, Qiaozhen Ye, Haiyang Yu, John Ravits, Cong Liu, John R Yates 3rd, Don W Cleveland

Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus

高渗应激诱导细胞核内 ALS 相关蛋白的液-液相分离

Chao Gao, Jinge Gu, Hong Zhang, Kai Jiang, Linlin Tang, Ren Liu, Li Zhang, Pengfei Zhang, Cong Liu, Bin Dai, Jie Song

Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

Hsp70 具有液-液相分离能力,并能与 FUS 分子伴侣结合,对抗淀粉样蛋白聚集

Yichen Li, Jinge Gu, Chen Wang, Jiaojiao Hu, Shenqing Zhang, Cong Liu, Shengnan Zhang, Yanshan Fang, Dan Li

Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway

烟酰胺 N-甲基转移酶通过其代谢物 1-甲基烟酰胺抑制 TGF-β1/Smad3 通路改善肾纤维化

Wenying Zhang, Guang Rong, Jinge Gu, Cuiling Fan, Tingting Guo, Tingting Jiang, Weiqian Deng, Jiayu Xie, Zhihua Su, Qimin Yu, Jingyi Mai, Rinan Zheng, Xingling Chen, Xun Tang, Jun Zhang

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

Hsp70 陪伴 TDP-43 处于动态、液态状态并防止其发生淀粉样蛋白聚集

Jinge Gu #, Chen Wang #, Rirong Hu #, Yichen Li, Shengnan Zhang, Yunpeng Sun, Qiangqiang Wang, Dan Li, Yanshan Fang, Cong Liu

Molecular structure of an amyloid fibril formed by FUS low-complexity domain

FUS 低复杂度结构域形成的淀粉样蛋白原纤维的分子结构

Yunpeng Sun, Shenqing Zhang, Jiaojiao Hu, Youqi Tao, Wencheng Xia, Jinge Gu, Yichen Li, Qin Cao, Dan Li, Cong Liu

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

低温电子显微镜结构揭示核定位序列介导 hnRNPA1 淀粉样蛋白原纤维的形成

Yunpeng Sun, Kun Zhao, Wencheng Xia, Guoqin Feng, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Renxiao Wang, Cong Liu, Dan Li

Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation

应激通过 Paraspeckle LncRNA NEAT1 介导的液-液相分离诱导动态、拮抗细胞毒性的 TDP-43 核体

Chen Wang, Yongjia Duan, Gang Duan, Qiangqiang Wang, Kai Zhang, Xue Deng, Beituo Qian, Jinge Gu, Zhiwei Ma, Shuang Zhang, Lin Guo, Cong Liu, Yanshan Fang

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

PARylation 调节应激颗粒动力学、相分离和疾病相关 RNA 结合蛋白的神经毒性

Yongjia Duan #, Aiying Du #, Jinge Gu #, Gang Duan, Chen Wang, Xinrui Gui, Zhiwei Ma, Beituo Qian, Xue Deng, Kai Zhang, Le Sun, Kuili Tian, Yaoyang Zhang, Hong Jiang, Cong Liu, Yanshan Fang