Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
发现 QCA570 是一种非常有效的靶向嵌合体 (PROTAC) 降解剂,能够诱导完全和持久的肿瘤消退,可降解溴结构域和额外末端 (BET) 蛋白
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b00506
Chong Qin, Yang Hu, Bing Zhou, Ester Fernandez-Salas, Chao-Yie Yang, Liu Liu, Donna McEachern, Sally Przybranowski, Mi Wang, Jeanne Stuckey, Jennifer Meagher, Longchuan Bai, Zhuo Chen, Mei Lin, Jiuling Yang, Danya N Ziazadeh, Fuming Xu, Jiantao Hu, Weiguo Xiang, Liyue Huang, Siwei Li, Bo Wen, Duxin