日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion

CGM23 是一种泛冠状病毒脂肽抑制剂,能有效抑制病毒颗粒融合。

Matsui, Yusuke; Schwarzer, Roland; Montano, Mauricio; Helmy, Ekram W; Suryawanshi, Rahul K; Taha, Taha Y; Wang, Yan; Angel, Yvonne; Adler, Marc; Sassano, M Flori; Jo, Hyunil; Tarran, Robert; Ott, Melanie; Greene, Warner C

Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation

由MAPT S305I突变引起的家族性额颞叶痴呆症中存在独特的tau蛋白丝折叠

Pan, Henry S; Merz, Gregory E; Li, Alissa Nana; Le, Minh Quan; Jo, Hyunil; Quddus, Athena; Yung, Anthony; Kormos, Rian C; Melo, Arthur A; Ramos, Eliana Marisa; Lago, Argentina Lario; Spina, Salvatore; Grinberg, Lea T; Rosen, Howard J; Tse, Eric; Gorno-Tempini, Maria Luisa; DeGrado, William F; Seeley, William W; Southworth, Daniel R

Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes

转位子介导的界面螺旋插入膜的序列依赖性尺度

Grau, Brayan; Kormos, Rian; Bañó-Polo, Manuel; Chen, Kehan; García-Murria, María J; Hajredini, Fatlum; Sánchez Del Pino, Manuel M; Jo, Hyunil; Martínez-Gil, Luis; von Heijne, Gunnar; DeGrado, William F; Mingarro, Ismael

Ion channel structure and function of the MERS coronavirus E protein

MERS冠状病毒E蛋白的离子通道结构和功能

Sučec, Iva; Xia, Bingqing; Somberg, Noah H; Wang, Yi; Jo, Hyunil; Li, Shuangqu; Perrone, Barbara; Gao, Zhaobing; Hong, Mei

Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells

纤连蛋白依赖性整合素信号通路驱动血管平滑肌细胞中 EphA2 的表达

Pearson-Gallion, Brenna; Finney, Alexandra C; Scott, Matthew L; Connelly, Zachary; Alam, Shafiul; Peretik, Jonette M; Ben Dhaou, Cyrine; Bhuiyan, Md Shenuarin; Traylor, James G Jr; DeGrado, William F; Jo, Hyunil; Yu, Xiuping; Rom, Oren; Pattillo, Christopher B; Dhanesha, Nirav; Yurdagul, Arif Jr; Orr, A Wayne

Structure-Based Discovery of Potent and Selective Small-Molecule α5β1 Integrin Inhibitors for Asthma Therapy

基于结构的高效选择性小分子α5β1整合素抑制剂的发现及其在哮喘治疗中的应用

Beresis, Richard; Sundaram, Aparna; Jo, Hyunil; Adler, Marc; Wang, Zheng; McIntosh, Joel; Yeon, Seul Ki; Huang, Qiuya; Ngo, Grace; Sheppard, Dean; DeGrado, William F

Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases.

探索一类芳基咪唑基脲作为强效酸性神经酰胺酶抑制剂在治疗纤维化疾病中的应用

Beresis Richard, Prathigudupu Vijaya, Cable Carson, Yu Amy, Adler Marc, Ramamoorthi Roopa, Yeon Seul Ki, Gordan John D, Sharma Sachin, DeGrado William F, Zaro Balyn, Chen Jennifer Y, Jo Hyunil

Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation

通过刺激 HSC 依赖性细胞外基质降解来消除纤维化

Sharma, Sachin; Prathigudupu, Vijaya; Cable, Carson; Serrano, Lia R; Nerella, Srilaxmi; Chen, Alina; Hassan, Ghmkin; Lakins, Johnathon; Valenzuela, Carlos Lizama; Tsukui, Tatsuya; Ramamoorthi, Roopa; Kim, Jae-Jun; Willenbring, Holger; Mattis, Aras N; Volk, Regan F; Zaro, Balyn W; Coon, Joshua J; Beresis, Richard; DeGrado, William F; Weaver, Valerie M; Christenson, Stephanie A; Jo, Hyunil; Chen, Jennifer Y

Oligomeric State and Drug Binding of the SARS-CoV-2 Envelope Protein Are Sensitive to the Ectodomain

SARS-CoV-2包膜蛋白的寡聚状态和药物结合对胞外结构域敏感。

Somberg, Noah H; Sučec, Iva; Medeiros-Silva, João; Jo, Hyunil; Beresis, Richard; Syed, Abdullah M; Doudna, Jennifer A; Hong, Mei

De novo design of peptides that bind specific conformers of α-synuclein

从头设计与α-突触核蛋白特定构象结合的肽。

Wallace, Hailey M; Yang, Hyunjun; Tan, Sophia; Pan, Henry S; Yang, Rose; Xu, Junyi; Jo, Hyunil; Condello, Carlo; Polizzi, Nicholas F; DeGrado, William F