Jochen Gaedcke相关文献与解析，生知库 | 链接生命科学的每一步

Jonas Buchloh ,Melanie Spitzner ,Hauke Zimmermann ,Xin Fang ,Constanza Tapia Contreras ,Carolin Schneider ,Tiago de Oliveria ,Stefan Küffer ,Michael Linnebacher ,Felix Rühlmann ,Lena Conradi ,Matthias Wirth ,Michael Ghadimi ,Marian Grade ,Jochen Gaedcke ,Günter Schneider

肿瘤

肠癌

KRAS

发表日期：2025

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KRASG 12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

基于 KRASG 12C 抑制剂的胰腺癌联合疗法：从药物筛选中获得的见解

期刊:Molecular Oncology

影响因子:5

doi:10.1002/1878-0261.13725

Constanza Tapia Contreras, Jonas Dominik Falke, Dana-Magdalena Seifert, Carolin Schneider, Lukas Krauß, Xin Fang, Denise Müller, Engin Demirdizen, Melanie Spitzner, Tiago De Oliveira, Christian Schneeweis, Jochen Gaedcke, Silke Kaulfuß, Kimia Mirzakhani, Bernd Wollnik, Karly Conrads, Tim Beißbarth,

LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism

LMO3 是基底样/鳞状亚型的抑制剂，通过甘油 3-磷酸代谢降低胰腺癌的疾病侵袭性

期刊:Carcinogenesis

影响因子:3.3

doi:10.1093/carcin/bgae011

Yuuki Ohara, Amanda J Craig, Huaitian Liu, Shouhui Yang, Paloma Moreno, Tiffany H Dorsey, Helen Cawley, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, Stefan Ambs, S Perwez Hussain

ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

ADRA2A 促进经典/祖细胞亚型并降低胰腺癌的疾病侵袭性

期刊:

影响因子:

doi:10.1101/2024.03.12.584316

Paloma Moreno, Yuuki Ohara, Amanda J Craig, Huaitian Liu, Shouhui Yang, Lin Zhang, Gatikrushna Panigrahi, Tiffany H Dorsey, Helen Cawley, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, S Perwez Hussain

SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

SERPINB3-MYC 轴诱导基底样/鳞状亚型并增强胰腺癌的疾病进展

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2023.113434

Yuuki Ohara, Wei Tang, Huaitian Liu, Shouhui Yang, Tiffany H Dorsey, Helen Cawley, Paloma Moreno, Raj Chari, Mary R Guest, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, Stefan Ambs, S Perwez Hussain

Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer

血清免疫检查点分析确定可溶性 CD40 为胰腺癌的生物标志物

期刊:npj Precision Oncology

影响因子:6.8

doi:10.1038/s41698-023-00459-9

David Digomann, Max Heiduk, Charlotte Reiche, Jessica Glück, Christoph Kahlert, Peter Mirtschink, Anna Klimova, Florian Bösch, Torsten Tonn, Jochen Gaedcke, Michael Ghadimi, Jürgen Weitz, Lena Seifert, Adrian M Seifert3

Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

在侵袭性胰腺导管腺癌中鉴定出 ΔNp63 依赖的 Basal-Like A 亚型特异性转录增强子程序 (B-STEP)

期刊:Molecular Cancer Research

影响因子:4.1

doi:10.1158/1541-7786.MCR-22-0916

Xin Wang #, Ana P Kutschat #, Joana Aggrey-Fynn, Feda H Hamdan, Rondell P Graham, Alexander Q Wixom, Yara Souto, Swetlana Ladigan-Badura, Jennifer A Yonkus, Amro M Abdelrahman, Roberto Alva-Ruiz, Jochen Gaedcke, Philipp Ströbel, Robyn Laura Kosinsky, Florian Wegwitz, Patrick Hermann, Mark J Truty, J

Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas

尿激酶型纤溶酶原激活剂受体 (uPAR) 与突变的 KRAS 协同调节胰腺腺癌的细胞可塑性和吉西他滨反应

期刊:Cancers

影响因子:

doi:10.3390/cancers15051587

Luogen Peng, Yuchan Li, Sha Yao, Jochen Gaedcke, Victor M Baart, Cornelis F M Sier, Albrecht Neesse, Volker Ellenrieder, Hanibal Bohnenberger, Frieder Fuchs, Julia Kitz, Philipp Ströbel, Stefan Küffer

Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy

术前活检的基因表达谱可预测直肠癌患者对术前放化疗的完全反应

期刊:British Journal of Cancer

影响因子:6.4

doi:10.1038/s41416-022-01842-2.

Georg Emons # ,Noam Auslander # ,Peter Jo # ,Julia Kitz ,Azadeh Azizian ,Yue Hu ,Clemens F Hess ,Claus Roedel ,Ulrich Sax ,Gabriela Salinas ,Philipp Stroebel ,Frank Kramer ,Tim Beissbarth ,Marian Grade ,Michael Ghadimi ,Eytan Ruppin ,Thomas Ried # ,Jochen Gaedcke #

Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy

靶向 STAT3 信号促进胰腺癌细胞对放化疗的响应

期刊:Cancers

影响因子:

doi:10.3390/cancers14051301

Hannah Flebbe, Melanie Spitzner, Philipp Enno Marquet, Jochen Gaedcke, B Michael Ghadimi, Stefan Rieken, Günter Schneider, Alexander O Koenig, Marian Grade

Pan-ERBB Inhibitors Synergize With KRAS Inhibitors in Rectal Cancer

泛ERBB抑制剂与KRAS抑制剂在直肠癌中具有协同作用

KRASG 12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

基于 KRASG 12C 抑制剂的胰腺癌联合疗法：从药物筛选中获得的见解

LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism

LMO3 是基底样/鳞状亚型的抑制剂，通过甘油 3-磷酸代谢降低胰腺癌的疾病侵袭性

ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

ADRA2A 促进经典/祖细胞亚型并降低胰腺癌的疾病侵袭性

SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

SERPINB3-MYC 轴诱导基底样/鳞状亚型并增强胰腺癌的疾病进展

Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer

血清免疫检查点分析确定可溶性 CD40 为胰腺癌的生物标志物

Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

在侵袭性胰腺导管腺癌中鉴定出 ΔNp63 依赖的 Basal-Like A 亚型特异性转录增强子程序 (B-STEP)

Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas

尿激酶型纤溶酶原激活剂受体 (uPAR) 与突变的 KRAS 协同调节胰腺腺癌的细胞可塑性和吉西他滨反应

Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy

术前活检的基因表达谱可预测直肠癌患者对术前放化疗的完全反应

Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy

靶向 STAT3 信号促进胰腺癌细胞对放化疗的响应