CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
利用 CRISPRi/a 对人类 iPSC-心肌细胞进行筛选,发现糖酵解激活是阿霉素诱导心脏毒性的一个可药物靶点。
期刊:Cell Stem Cell
影响因子:19.8
doi:10.1016/j.stem.2024.10.007
Chun Liu ,Mengcheng Shen ,Yanxia Liu ,Amit Manhas ,Shane Rui Zhao ,Mao Zhang ,Nadjet Belbachir ,Lu Ren ,Joe Z Zhang ,Arianne Caudal ,Masataka Nishiga ,Dilip Thomas ,Angela Zhang ,Huaxiao Yang ,Yang Zhou ,Mohamed Ameen ,Nazish Sayed ,June-Wha Rhee ,Lei S Qi ,Joseph C Wu