日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Platelet Autophagy as a Druggable Intracellular Pathway: Therapeutic Opportunities in Thromboinflammatory Diseases

血小板自噬作为一种可药物靶向的细胞内通路：血栓炎症性疾病的治疗契机

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics18030293
Yen, Ting-Lin; Jan, Jing-Shiun; Teng, Ruei-Dun; Ko, Pi-Chan; Taliyan, Rajeev; Yang, Chih-Hao; Sun, Jui-Ming; Sheu, Joen-Rong
血小板
炎症
炎症/感染
信号转导
心血管
Autophagy
细胞生物学
自噬
发表日期：2026
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Distinct Thromboxane A₂-Dependent Pathways Regulate Arachidonic Acid-Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition

不同的血栓素A₂依赖性通路调节人血小板中花生四烯酸触发的VASP在Ser239和Ser157位点的磷酸化：实时可视化显示，靶向血栓素A₂信号通路比抑制环氧合酶具有更优的抗血栓疗效

期刊:Journal of Cellular Physiology
影响因子:4
doi:10.1002/jcp.70160
Sheu, Joen-Rong; Huang, Wei-Chieh; Chang, Chao-Chien; Hsia, Chih-Wei; Hsia, Chih-Hsuan; Jayakumar, Thanasekaran; Hou, Shaw-Min
血小板
VASP
信号转导
心血管
Human
磷酸化
发表日期：2026
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A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia

一种新型的基于KGD的αIIbβ3拮抗剂可预防动脉血栓形成，同时保持止血功能并避免血小板减少症。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26104530
Kuo, Yu-Ju; Chung, Ching-Hu; Chen, Chun-Chao; Liu, Ju-Chi; Chiou, Kuan-Rau; Sheu, Joen-Rong; Chuang, Woei-Jer; Huang, Tur-Fu
血小板
心血管
发表日期：2025
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Lipopolysaccharide Potentiates Platelet Aggregation in Association with Apoptosis Through a Novel TLR4-Bax/Bcl-2-Mitochondrial Dysfunction Axis in Humans

脂多糖通过新型TLR4-Bax/Bcl-2-线粒体功能障碍轴增强血小板聚集并促进细胞凋亡

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom15121638
Chen, Chun-Chao; Hsia, Chih-Wei; Huang, Wei-Chieh; Chang, Chao-Chien; Darmanto, Arief Gunawan; Sheu, Joen-Rong
血小板
Bcl-2
凋亡
表观遗传
Apoptosis
TLR4
Human
线粒体
细胞生物学
发表日期：2025
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Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models

丁香酚抑制血小板活化并减轻人类和小鼠模型中的肺血栓栓塞

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms25042098
Huang, Wei-Chieh; Shu, Lan-Hsin; Kuo, Yu-Ju; Lai, Kevin Shu-Leung; Hsia, Chih-Wei; Yen, Ting-Lin; Hsia, Chih-Hsuan; Jayakumar, Thanasekaran; Yang, Chih-Hao; Sheu, Joen-Rong
血小板
Human
心血管
发表日期：2024
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Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLCγ2 but not cyclic nucleotide-dependent pathway in human

银杏黄素通过PLCγ2途径而非环核苷酸依赖性途径有效减轻胶原蛋白和花生四烯酸诱导的血小板活化。

期刊:Journal of Cellular and Molecular Medicine
影响因子:4.2
doi:10.1111/jcmm.18139
Hsia, Chih-Wei; Shu, Lan-Hsin; Lee, Ai-Wei; Tran, Oanh-Thi; Yang, Chih-Hao; Yen, Ting-Lin; Huang, Wei-Chieh; Hsia, Chih-Hsuan; Jayakumar, Thanasekaran; Chiou, Kuan-Rau; Sheu, Joen-Rong
血小板
发表日期：2024
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Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis

丁香酚：通过创新的cPLA2-NF-κB信号轴调节人血小板活化和鼠肠系膜血管血栓形成的潜在调节剂

期刊:Biomedicines
影响因子:3.9
doi:10.3390/biomedicines12081689
Chang, Yi; Hsia, Chih-Wei; Chiou, Kuan-Rau; Yen, Ting-Lin; Jayakumar, Thanasekaran; Sheu, Joen-Rong; Huang, Wei-Chieh
血小板
信号转导
NF-κB
心血管
Human
Mouse
cPLA2
发表日期：2024
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Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma

针对昼夜节律蛋白 Rev-erbα 来缓解炎症、氧化应激并增强脑外伤后的功能恢复

期刊:Antioxidants
影响因子:
doi:10.3390/antiox13080901
Arief Gunawan Darmanto, Jing-Shiun Jan, Ting-Lin Yen, Shin-Wei Huang, Ruei-Dun Teng, Jia-Yi Wang, Rajeev Taliyan, Joen-Rong Sheu, Chih-Hao Yang
表观遗传
发表日期：2024
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Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

同侧半球局部清除衰老细胞的能力可减轻小鼠急性缺血性脑损伤

期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.84060
Lu, Kuan-Jung; Sheu, Joen-Rong; Teng, Ruei-Dun; Jayakumar, Tanasekar; Chung, Chi-Li; Hsieh, Cheng-Ying
细胞生物学
衰老
神经科学
发表日期：2023
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Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets

光甘草定抑制人血小板中整合素 αIIbβ3 由内向外信号和 NF-κB 活化的机制

期刊:Chinese Medicine
影响因子:5.3
doi:10.1186/s13020-023-00779-9
Wei-Chieh Huang #, Thanasekaran Jayakumar, Joen-Rong Sheu #, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Lin Yen, Chao-Chien Chang
信号转导
血小板
NF-κB
Human
发表日期：2023
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