日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial

肿瘤减瘤联合化疗治疗多器官转移性结直肠癌:ORCHESTRA随机临床试验

Gootjes, Elske C; Bakkerus, Lotte; Adhin, Anviti A; Zonderhuis, Barbara M; Versteeg, Kathelijn S; Tuynman, Jurriaan B; Meijerink, Martijn R; Haasbeek, Cornelis J A; de Wilt, Johannes H W; Grunhagen, Dirk J; Smit, Ewoud J; Primrose, John M; Bridgewater, John; van Meerten, Esther; de Groot, Jan-Willem B; Hendriks, Mathijs P; Oomen-de Hoop, Esther; Buffart, Tineke E; Verhoef, Cornelis; Verheul, Henk M W

Prethermalization by random multipolar driving on a 78-qubit processor

在78量子比特处理器上通过随机多极驱动实现预热

Liu, Zheng-He; Liu, Yu; Liang, Gui-Han; Deng, Cheng-Lin; Chen, Keyang; Shi, Yun-Hao; Li, Tian-Ming; Zhang, Lv; Chen, Bing-Jie; Fang, Cai-Ping; Feng, Da'er; Gu, Xu-Yang; He, Yang; Huang, Kaixuan; Li, Hao; Liu, Hao-Tian; Li, Li; Mei, Zheng-Yang; Peng, Zhen-Yu; Song, Jia-Cheng; Wang, Ming-Chuan; Wang, Shuai-Li; Wang, Ziting; Xiao, Yongxi; Xu, Minke; Xu, Yue-Shan; Yan, Yu; Yu, Yi-Han; Yuan, Wei-Ping; Zhang, Jia-Chi; Zhao, Jun-Jie; Zhao, Kui; Zhou, Si-Yun; Wang, Zheng-An; Song, Xiaohui; Tian, Ye; Mintert, Florian; Knolle, Johannes; Moessner, Roderich; Zhang, Yu-Ran; Zhang, Pan; Xiang, Zhongcheng; Zheng, Dongning; Xu, Kai; Zhao, Hongzheng; Fan, Heng

LetA defines a structurally distinct transporter family.

LetA 定义了一个结构独特的转运蛋白家族。

Santarossa Cristina C, Li Yupeng, Yousef Sara, Hasdemir Hale S, Rodriguez Carlos C, Haase Max A B, Baek Minkyung, Coudray Nicolas, Pavek John G, Focke Kimber N, Silverberg Annika L, Bautista Carmelita, Yeh Johannes T-H, Marty Michael T, Baker David, Tajkhorshid Emad, Ekiert Damian C, Bhabha Gira

Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

衰老会促进小胶质细胞中缓慢降解的突触蛋白的积累。

Guldner Ian H, Wagner Viktoria P, Moran-Losada Patricia, Shi Sophia M, Golub Sophia W, Hevler Johannes F, Chen Kelly, Meese Barbara T, Ghoochani Ali, Pulido Ernst, Oh Hamilton Se-Hwee, Le Guen Yann, Lu Nannan, Wong Pui Shuen, To Ning-Sum, Garceau Dylan, Guo Zimin, Luo Jian, Bertozzi Carolyn R, Lundberg Emma, Abu-Remaileh Monther, Sasner Michael, Keller Andreas, Yang Andrew C, Cheung Tom H, Wyss-Coray Tony

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance.

活化的 ATF6α 是肝肿瘤的驱动因子,可限制免疫监视。

Li Xin, Lebeaupin Cynthia, Kadianaki Aikaterini, Druelle-Cedano Clementine, Vesper Niklas, Rennert Charlotte, Huguet-Pradell Júlia, Gomez Ramos Borja, Fan Chaofan, Piecyk Robert Stefan, Zizmare Laimdota, Ramadori Pierluigi, Li Luqing, Frick Lukas, Qiu Menjie, Zhang Cangang, Martins Nascentes Melo Luiza, Ranvir Vikas Prakash, Shen Peng, Hanselmann Johannes, Kosla Jan, Fernández-Vaquero Mirian, Vucur Mihael, Baskaran Praveen, Bao Xuanwen, Coleman Olivia I, Tang Yingyue, Cetin Miray, Chen Zhouji, Jang Insook, Del Prete Stefania, Rahbari Mohammad, Zhang Peng, Pham Timothy V, Hou Yushan, Sun Aihua, Gu Li, Kim Laura C, Rothermel Ulrike, Heide Danijela, Ali Adnan, Gallage Suchira, Talvard-Balland Nana, Piqué-Gili Marta, Gris-Oliver Albert, Bevilacqua Alessio, Schlicker Lisa, Duffey Alec, Unger Kristian, Szydlowska Marta, Hetzer Jenny, Odom Duncan T, Machauer Tim, Bucci Daniele, Sant Pooja, Lee Jun-Hoe, Rösler Jonas, Meckelmann Sven W, Schreck Johannes, Murray Sue, Simon M Celeste, Nahnsen Sven, Schulze Almut, Ho Ping-Chih, Jugold Manfred, Breuhahn Kai, Mallm Jan-Philipp, Schirmacher Peter, Roth Susanne, Rahbari Nuh, Tschaharganeh Darjus F, Roessler Stephanie, Goeppert Benjamin, Bengsch Bertram, Andrieux Geoffroy, Boerries Melanie, Malek Nisar P, Prinz Marco, Weber Achim, Zeiser Robert, Tamayo Pablo, Bronsert Peter, Kurowski Konrad, Thimme Robert, Yuan Detian, Carretero Rafael, Luedde Tom, Pinyol Roser, Hartmann Felix J, Karin Michael, Tasdogan Alpaslan, Trautwein Christoph, Mall Moritz, Hofmann Maike, Llovet Josep M, Haller Dirk, Kaufman Randal J, Heikenwälder Mathias

Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve

全基因组和转录组分析鉴定出多个候选基因,并揭示了二叶式主动脉瓣中显著的多基因贡献

Thériault, Sébastien; Holdcraft, Jacob A; Sharipova, Dinara; Faucherre, Adèle; Debiec, Radoslaw M; Peloso, Gina M; Al-Kassou, Baravan; Aranki, Sary; Ashikhmina Swan, Elena; Ballotta, Andrea; Bellino, Michele; Björck, Hanna M; Boureau, Anne Sophie; Braund, Peter S; Corriveau, François; Dagenais, François; Folkersen, Lasse; Forte, Amalia; Francke, Michael D; Frigiola, Alessandro; Gorbatov, Svetlana; Guo, Dongchuan; Habchi, Karam M; Heydarpour, Mahyar; Isselbacher, Eric M; Jopling, Chris; Laporte, Fabien; Le Scouarnec, Solena; Li, Zhonglin; Lichtner, Peter; Maj, Carlo; Manikpurage, Hasanga D; Nelson, Christopher P; Nguyen, Thy B; Norris, Russell A; Ong, Chin Siang; Pibarot, Philippe; Roychowdhury, Tanmoy; Sarubbi, Berardo; Simonet, Floriane; Sundt, Thoralf; Surakka, Ida; Tessler, Idit; Willer, Cristen J; Wittmann, Susanne; Yang, Bo; Berezovets, Igor; Doppler, Stefanie A; Dreßen, Martina; Knoll, Katharina; Puehler, Thomas; Schunkert, Heribert; Avierinos, Jean-François; Bissell, Malenka M; Bolger, Aidan P; Bossé, Yohan; Bossone, Eduardo; Brion, María; Citro, Rodolfo; de Vincentiis, Carlo; Deeb, G Michael; Della Corte, Alessandro; Dina, Christian; Durst, Ronen; Ensminger, Stephan; Eriksson, Per; Evangelista, Arturo; Franco-Cereceda, Anders; Gilon, Dan; Giusti, Betti; Hetherington, Simon L; Huggins, Gordon S; Krane, Markus; Le Tourneau, Thierry; Limongelli, Giuseppe; Mathieu, Patrick; Messika-Zeitoun, David; Michelena, Hector I; Milewicz, Dianna; Muehlschlegel, Jochen D; Murdock, David R; Nickenig, Georg; Nistri, Stefano; Nöthen, Markus M; Pluchinotta, Francesca; Prakash, Siddharth K; Samani, Nilesh J; Schott, Jean-Jacques; Webb, Tom R; Zaffran, Stéphane; Abdelilah-Seyfried, Salim; Eagle, Kim; Schumacher, Johannes; Trenkwalder, Teresa; Body, Simon C

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

转移性结直肠癌中 EMP1+ 到 LGR5+ 细胞状态的转化可绕过 KRASG12D 药物抑制。

Centonze Alessia, Roura Adrià-Jaume, Novillo-Font Meritxell, Giordano Cristina, Hernando-Momblona Xavier, Llanses Montserrat, Prats Paula, Sevillano Marta, Cabot Débora, Novell Mireia, Pabst Gabriel, Andersch Florian, Cañellas-Socias AdriÃ, Zhang Chong, Giakoumakis Nikolaos-Nikiforos, Sparks Hugh, Dunsby Chris, Colombelli Julien, Fernández-Barral Asunción, Sancho Elena, Stephan-Otto Attolini Camille, Muñoz Alberto, Barbachano Antonio, Palmer Héctor G, Martínez-Quintanilla Jordi, Zuber Johannes, Blaj Cristina, Quintana Elsa, Cortina Carme, Marti-Renom Marc A, Batlle Eduard

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.

主动脉狭窄的基因组学和转录组学分析有助于发现治疗靶点和预测疾病。

Small Aeron M, Yang Ta-Yu, Itoh Shinsuke, Thériault Sébastien, Dufresne Line, Kurosawa Ryo, Komuro Issei, Matsuda Koichi, Vy Ha My T, Farber-Eger Eric H, Shaffer Lauren Lee, Boulier Kristin M, Corey Kristin M, Ramaker Megan E, Laporte Fabien, Schott Jean-Jacques, Le Scouarnec Solena, Singh Sasha A, Sonawane Abhijeet R, Smith Harry A, Rafaels Nicholas, Ghouse Jonas, Raja Anna A, Ostrowski Sisse R, Sørensen Erik, Mikkelsen Christina, Pedersen Ole B, Erikstrup Christian, Ullum Henrik, Sveinbjornsson Gardar, Gudbjartsson Daniel F, Abner Erik, Lee Jiwoo, Ganna Andrea, Nowak-Göttl Ulrike, Finer Sarah, Schumacher Johannes, Maj Carlo, Al-Kassou Baravan, Nickenig Georg, Trenkwalder Teresa, Dreβen Martina, Krane Markus, Nöthen Markus M, Moksnes Marta R, Brumpton Ben M, Knight Stacey, Knowlton Kirk U, Nadauld Lincoln, Debiec Radek, Musameh Muntaser D, Braund Peter S, Nelson Christopher P, Czuba Tomasz, Melander Olle, Selvaraj Margaret Sunitha, Koyama Satoshi, Bhukar Rohan, Ruan Yunfeng, Ljungberg Johan, Damrauer Scott M, Levin Michael G, Franke Andre, Berger Klaus, Ruff Christian T, Melloni Giorgio E M, Kamanu Frederick K, Ito Kaoru, Do Ron, Loos Ruth J F, Schunkert Heribert, Wells Quinn S, Shah Svati H, Le Tourneau Thierry, Messika-Zeitoun David, Gignoux Christopher, Bundgaard Henning, Larsson Susanna C, Michaëlsson Karl, Holm Hilma, Helgadottir Anna, Esko Tonu, van Heel David A, Mathieu Patrick, Samani Nilesh J, Smith J Gustav, Söderberg Stefan, Rader Daniel J, Marston Nicholas A, Sabatine Marc S, Pasaniuc Bogdan, Cho Kelly, Wilson Peter W F, O'Donnell Christopher J, Stefansson Kari, Bossé Yohan, Aikawa Elena, Engert James C, Peloso Gina M, Natarajan Pradeep, Thanassoulis George

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

基质来源趋化因子网络的重编程驱动淋巴结B细胞淋巴瘤组织结构的丧失

Czernilofsky, Felix; Mathioudaki, Anna; Jopp-Saile, Lea; Lutz, Raphael; Vonficht, Dominik; Wang, Xi; Schniederjohann, Christina; Voehringer, Harald; Roider, Tobias; Baertsch, Marc-Andrea; Rodemer, Claus; Löffler-Wirth, Henry; Grau, Michael; Fitzgerald, Donnacha; Mammen, Johannes; Kosla, Jan; Liebers, Nora; Bruch, Peter-Martin; Ordoñez-Rueda, Diana; Brobeil, Alexander; Mechtersheimer, Gunhild; Pabst, Caroline; Müller-Tidow, Carsten; Trumpp, Andreas; Seifert, Marc; Neumann, Frank; Heikenwälder, Mathias; Benes, Vladimir; Huber, Wolfgang; Distler, Jörg; Lenz, Georg; Binder, Hans; Siebert, Reiner; Nolan, Garry P; Gerstung, Moritz; Zaugg, Judith B; Hübschmann, Daniel; Haas, Simon; Dietrich, Sascha