Johansson Jan O相关文献与解析，生知库 | 链接生命科学的每一步

A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3

一种新型的apoE模拟物可提高表达APOE3的雄性小鼠脑内apoE水平，减少Aβ病理，并在病理发生前进行治疗以改善记忆力。

Valencia-Olvera, Ana C; Balu, Deebika; Bellur, Shreya; McNally, Thomas; Saleh, Yaseen; Pham, Don; Ghura, Shivesh; York, Jason; Johansson, Jan O; LaDu, Mary Jo; Tai, Leon

APOE

神经科学

发表日期：2023

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Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys

ABCA1激动剂CS-6253对食蟹猴β-淀粉样蛋白和脂蛋白代谢的影响

期刊:Alzheimers Research & Therapy

影响因子:7.6

doi:10.1186/s13195-022-01028-1

Noveir, Sasan D; Kerman, Bilal E; Xian, Haotian; Meuret, Cristiana; Smadi, Sabrina; Martinez, Ashley E; Johansson, Johannes; Zetterberg, Henrik; Parks, Bryan A; Kuklenyik, Zsuzsanna; Mack, Wendy J; Johansson, Jan O; Yassine, Hussein N

Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study

阿帕贝他隆与急性冠脉综合征后患者心力衰竭住院治疗：BETonMACE 研究的预设分析

期刊:Cardiovascular Diabetology

影响因子:10.6

doi:10.1186/s12933-020-01199-x

Nicholls, Stephen J; Schwartz, Gregory G; Buhr, Kevin A; Ginsberg, Henry N; Johansson, Jan O; Kalantar-Zadeh, Kamyar; Kulikowski, Ewelina; Toth, Peter P; Wong, Norman; Sweeney, Michael; Ray, Kausik K

Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial

胰岛素治疗2型糖尿病与急性冠脉综合征后主要不良心血管事件风险的关系：BETonMACE随机临床试验分析

期刊:Cardiovascular Diabetology

影响因子:10.6

doi:10.1186/s12933-021-01311-9

Schwartz, Gregory G; Nicholls, Stephen J; Toth, Peter P; Sweeney, Michael; Halliday, Christopher; Johansson, Jan O; Wong, Norman C W; Kulikowski, Ewelina; Kalantar-Zadeh, Kamyar; Ginsberg, Henry N; Ray, Kausik K

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

神经元ROS诱导的胶质细胞脂滴形成会因阿尔茨海默病相关基因的缺失而发生改变

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2112095118

Moulton, Matthew J; Barish, Scott; Ralhan, Isha; Chang, Jinlan; Goodman, Lindsey D; Harland, Jake G; Marcogliese, Paul C; Johansson, Jan O; Ioannou, Maria S; Bellen, Hugo J

Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial

阿帕贝隆对糖尿病、慢性肾病和近期急性冠脉综合征患者心血管事件的影响：来自 BETonMACE 随机对照试验的结果

期刊:Clinical Journal of the American Society of Nephrology

影响因子:7.1

doi:10.2215/CJN.16751020

Kalantar-Zadeh, Kamyar; Schwartz, Gregory G; Nicholls, Stephen J; Buhr, Kevin A; Ginsberg, Henry N; Johansson, Jan O; Kulikowski, Ewelina; Lebioda, Kenneth; Toth, Peter P; Wong, Norman; Sweeney, Michael; Ray, Kausik K

Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial

BET蛋白抑制剂阿帕贝隆的认知效应：一项嵌套于BETonMACE随机对照试验中的预设蒙特利尔认知评估分析

期刊:Journal of Alzheimers Disease

影响因子:3.1

doi:10.3233/JAD-210570

Cummings, Jeffrey; Schwartz, Gregory G; Nicholls, Stephen J; Khan, Aziz; Halliday, Chris; Toth, Peter P; Sweeney, Michael; Johansson, Jan O; Wong, Norman C W; Kulikowski, Ewelina; Kalantar-Zadeh, Kamyar; Lebioda, Kenneth; Ginsberg, Henry N; Winblad, Bengt; Zetterberg, Henrik; Ray, Kausik K

神经科学

发表日期：2021

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Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial

阿帕贝隆联合标准治疗对近期发生急性冠脉综合征和2型糖尿病患者主要不良心血管事件的影响：一项随机临床试验

期刊:Journal of the American Medical Association

影响因子:55

doi:10.1001/jama.2020.3308

Ray, Kausik K; Nicholls, Stephen J; Buhr, Kevin A; Ginsberg, Henry N; Johansson, Jan O; Kalantar-Zadeh, Kamyar; Kulikowski, Ewelina; Toth, Peter P; Wong, Norman; Sweeney, Michael; Schwartz, Gregory G

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

BET蛋白抑制剂apabetalone（RVX-208）可抑制心血管疾病和2型糖尿病患者单核细胞的促炎性过度活化。

期刊:Clinical Epigenetics

影响因子:4.4

doi:10.1186/s13148-020-00943-0

Wasiak, Sylwia; Dzobo, Kim E; Rakai, Brooke D; Kaiser, Yannick; Versloot, Miranda; Bahjat, Mahnoush; Stotz, Stephanie C; Fu, Li; Sweeney, Michael; Johansson, Jan O; Wong, Norman C W; Stroes, Erik S G; Kroon, Jeffrey; Kulikowski, Ewelina

ABCA1: A Therapeutic Target for Improving Cholesterol Homeostasis in Peripheral Neuropathies

ABCA1：改善周围神经病变胆固醇稳态的治疗靶点

A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3

一种新型的apoE模拟物可提高表达APOE3的雄性小鼠脑内apoE水平，减少Aβ病理，并在病理发生前进行治疗以改善记忆力。

Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys

ABCA1激动剂CS-6253对食蟹猴β-淀粉样蛋白和脂蛋白代谢的影响

Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study

阿帕贝他隆与急性冠脉综合征后患者心力衰竭住院治疗：BETonMACE 研究的预设分析

Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial

胰岛素治疗2型糖尿病与急性冠脉综合征后主要不良心血管事件风险的关系：BETonMACE随机临床试验分析

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

神经元ROS诱导的胶质细胞脂滴形成会因阿尔茨海默病相关基因的缺失而发生改变

Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial

阿帕贝隆对糖尿病、慢性肾病和近期急性冠脉综合征患者心血管事件的影响：来自 BETonMACE 随机对照试验的结果

Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial

BET蛋白抑制剂阿帕贝隆的认知效应：一项嵌套于BETonMACE随机对照试验中的预设蒙特利尔认知评估分析

Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial

阿帕贝隆联合标准治疗对近期发生急性冠脉综合征和2型糖尿病患者主要不良心血管事件的影响：一项随机临床试验

BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

BET蛋白抑制剂apabetalone（RVX-208）可抑制心血管疾病和2型糖尿病患者单核细胞的促炎性过度活化。