日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC

新型 CEP1347-VHL-02 PROTAC 化合物选择性降解 MLK3,限制 TNBC 的致癌潜力

Kamila Karpińska, Dawid Mehlich, Venkata R Sabbasani, Michał Łomiak, Pedro Torres-Ayuso, Katarzyna Wróbel, Vi Nguyen-Phuong Truong, Remigiusz Serwa, Rolf E Swenson, John Brognard, Anna A Marusiak

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

PIM1靶向降解可预防前列腺癌化疗耐药性的出现

Pedro Torres-Ayuso ,Meghri Katerji ,Dawid Mehlich ,Sophia A Lookingbill ,Venkata R Sabbasani ,Hope Liou ,Andrea L Casillas ,Shailender S Chauhan ,Remigiusz Serwa ,Maxine R Rubin ,Anna A Marusiak ,Rolf E Swenson ,Noel A Warfel ,John Brognard

TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy

TNIK 抑制使 TNIK 过表达的肺鳞状细胞癌对放射治疗敏感

Triet Nguyen, Francesca Anna Carrieri, Nick Connis, Audrey Lafargue, Jinhee Chang, Aaron Chan, Amol C Shetty, Yang Song, Tung Hoang, Shreya Jagtap, Dipanwita Dutta Chowdhury, Muhammad Ajmal Khan, Kathleen L Gabrielson, Mohammad Rezaee, Pedro Torres-Ayuso, John Brognard, Christine L Hann, Phuoc T Tra

Serine-linked PARP1 auto-modification controls PARP inhibitor response

丝氨酸连接的PARP1自我修饰控制PARP抑制剂反应

Evgeniia Prokhorova #, Florian Zobel #, Rebecca Smith, Siham Zentout, Ian Gibbs-Seymour, Kira Schützenhofer, Alessandra Peters, Joséphine Groslambert, Valentina Zorzini, Thomas Agnew, John Brognard, Michael L Nielsen, Dragana Ahel, Sébastien Huet, Marcin J Suskiewicz, Ivan Ahel

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells

蛋白激酶 MAP3K19 磷酸化 MAP2K,从而激活 ERK 和 JNK 激酶,提高 KRAS 突变肺癌细胞的活力

Van T Hoang, Katherine Nyswaner, Pedro Torres-Ayuso, John Brognard

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin

信号通路筛选平台是识别缺乏已知驱动突变的癌症治疗靶点的有效方法:一例原发性不明癌症病例报告

Pedro Torres-Ayuso, Sudhakar Sahoo, Garry Ashton, Elvira An, Nicole Simms, Melanie Galvin, Hui Sun Leong, Kristopher K Frese, Kathryn Simpson, Natalie Cook, Andrew Hughes, Crispin J Miller, Richard Marais, Caroline Dive, Matthew G Krebs, John Brognard

Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation

阿尔茨海默病中的蛋白激酶 Cα 功能获得性变体通过逃避下调的机制表现出增强的催化作用

Julia A Callender, Yimin Yang, Gema Lordén, Natalie L Stephenson, Alexander C Jones, John Brognard, Alexandra C Newton

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

体细胞突变的 ABL1 是一种可操作且必需的 NSCLC 生存基因

Ewelina Testoni, Natalie L Stephenson, Pedro Torres-Ayuso, Anna A Marusiak, Eleanor W Trotter, Andrew Hudson, Cassandra L Hodgkinson, Christopher J Morrow, Caroline Dive, John Brognard

Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy

转录抑制因子 DAXX 通过抑制自噬促进前列腺癌的致瘤性

Lorena A Puto, John Brognard, Tony Hunter

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

混合谱系激酶独立于 RAF 激活 MEK,从而介导对 RAF 抑制剂的耐药性

Anna A Marusiak, Zoe C Edwards, Willy Hugo, Eleanor W Trotter, Maria R Girotti, Natalie L Stephenson, Xiangju Kong, Michael G Gartside, Shameem Fawdar, Andrew Hudson, Wolfgang Breitwieser, Nicholas K Hayward, Richard Marais, Roger S Lo, John Brognard