Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors
发现 3-烷氧基氨基-5-(吡啶-2-基氨基)吡嗪-2-腈作为选择性、口服生物可利用的 CHK1 抑制剂
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm3012933
Michael Lainchbury, Thomas P Matthews, Tatiana McHardy, Kathy J Boxall, Michael I Walton, Paul D Eve, Angela Hayes, Melanie R Valenti, Alexis K de Haven Brandon, Gary Box, G Wynne Aherne, John C Reader, Florence I Raynaud, Suzanne A Eccles, Michelle D Garrett, Ian Collins
