日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy

P329G-engager:一种用于癌症免疫治疗的通用型抗体基接头平台,可进行多种组合搭配。

Marlena Surowka ,Diana Darowski ,Idil Hutter-Karakoc ,Christina Claus ,Claudia Ferrara-Koller ,Anne Freimoser-Grundschober ,Thomas Hofer ,Johannes Sam ,Reto Gianotti ,Andrzej Sobieniecki ,Denis Assisi ,John Challier ,Stephane Leclair ,Ekkehard Mössner ,Maria Amann ,Pablo Umaña ,Christian Klein

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy

JAK和mTOR抑制剂可阻止细胞因子释放,同时保持T细胞双特异性抗体的体内疗效。

Gabrielle Leclercq ,Hélène Haegel ,Alberto Toso ,Tina Zimmermann ,Luke Green ,Nathalie Steinhoff ,Johannes Sam ,Vesna Pulko ,Anneliese Schneider ,Anna Maria Giusti ,John Challier ,Anne Freimoser-Grundschober ,Laurent Larivière ,Alex Odermatt ,Martin Stern ,Pablo Umana ,Marina Bacac ,Christian Klein

Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils

剖析 T 细胞介导者诱导的细胞因子释放机制,突出中性粒细胞的贡献

Gabrielle Leclercq, Llucia Alberti Servera, Sabrina Danilin, John Challier, Nathalie Steinhoff, Claudia Bossen, Alex Odermatt, Valeria Nicolini, Pablo Umaña, Christian Klein, Marina Bacac, Anna-Maria Giusti, Anneliese Schneider, Hélène Haegel

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies

Src/lck抑制剂达沙替尼可逆性地关闭T细胞双特异性抗体刺激后的细胞因子释放和T细胞细胞毒性

Gabrielle Leclercq ,Hélène Haegel ,Anneliese Schneider ,Anna Maria Giusti ,Estelle Marrer-Berger ,Christophe Boetsch ,Antje-Christine Walz ,Vesna Pulko ,Johannes Sam ,John Challier ,Cristiano Ferlini ,Alex Odermatt ,Pablo Umaña ,Marina Bacac ,Christian Klein

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

CAR-J 细胞用于抗体发现和 TCR 样免疫球蛋白的先导优化

Christian Jost, Diana Darowski, John Challier, Vesna Pulko, Lydia J Hanisch, Wei Xu, Ekkehard Mössner, Alexander Bujotzek, Stefan Klostermann, Pablo Umana, Roland E Kontermann, Christian Klein