日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone

接受尸体垂体衍生生长激素治疗的患者罹患医源性阿尔茨海默病

Gargi Banerjee, Simon F Farmer, Harpreet Hyare, Zane Jaunmuktane, Simon Mead, Natalie S Ryan, Jonathan M Schott, David J Werring, Peter Rudge, John Collinge

A structural basis for prion strain diversity

朊病毒菌株多样性的结构基础

Szymon W Manka, Adam Wenborn, Jemma Betts, Susan Joiner, Helen R Saibil, John Collinge, Jonathan D F Wadsworth

Two mouse models of Alzheimer's disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein

两种阿尔茨海默病小鼠模型以不同的速度积累淀粉样蛋白,并具有不同的 Aβ 寡聚体谱,且不会因细胞朊病毒蛋白的消融而改变

Silvia A Purro, Michael Farmer, Elizabeth Noble, Claire J Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X Thomas, Mark Farrow, Andrew J Nicoll, Dominic Walsh, John Collinge

2.7 Å cryo-EM structure of ex vivo RML prion fibrils

离体 RML 朊病毒原纤维的 2.7 Å 冷冻电镜结构

Szymon W Manka, Wenjuan Zhang, Adam Wenborn, Jemma Betts, Susan Joiner, Helen R Saibil, John Collinge, Jonathan D F Wadsworth

A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody

高内涵神经元成像分析表明抗朊病毒蛋白抗体可抑制朊病毒疾病相关的神经毒性

Madeleine Reilly, Iryna Benilova, Azadeh Khalili-Shirazi, Christian Schmidt, Parvin Ahmed, Daniel Yip, Parmjit S Jat, John Collinge

Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

巴西素通过改变构象平衡,从帕金森脑中去除有毒的 α-突触核蛋白并植入活性组装体

George R Nahass, Yuanzi Sun, Yong Xu, Mark Batchelor, Madeleine Reilly, Iryna Benilova, Niraja Kedia, Kevin Spehar, Frank Sobott, Richard B Sessions, Byron Caughey, Sheena E Radford, Parmjit S Jat, John Collinge, Jan Bieschke

Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease

散发性克雅氏病患者血液中 DNA 甲基化谱发生改变

Luke C Dabin, Fernando Guntoro, Tracy Campbell, Tony Bélicard, Adam R Smith, Rebecca G Smith, Rachel Raybould, Jonathan M Schott, Katie Lunnon, Peter Sarkies, John Collinge, Simon Mead, Emmanuelle Viré

Highly infectious prions are not directly neurotoxic

高传染性朊病毒并不直接具有神经毒性

Iryna Benilova, Madeleine Reilly, Cassandra Terry, Adam Wenborn, Christian Schmidt, Aline T Marinho, Emmanuel Risse, Huda Al-Doujaily, Michael Wiggins De Oliveira, Malin K Sandberg, Jonathan D F Wadsworth, Parmjit S Jat, John Collinge

PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity

PrP 嫁接抗体可结合某些淀粉样 β 蛋白聚集体,但不能预防毒性

David Mengel, Wei Hong, Grant T Corbett, Wen Liu, Alexandra DeSousa, Laura Solforosi, Cheng Fang, Matthew P Frosch, John Collinge, David A Harris, Dominic M Walsh

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown

额颞叶痴呆症致病基因 CHMP2B 通过敲低 TMEM106B 损害神经元内溶酶体交通救援

Emma L Clayton, Carmelo Milioto, Bhavana Muralidharan, Frances E Norona, James R Edgar, Armand Soriano, Paymaan Jafar-Nejad, Frank Rigo, John Collinge, Adrian M Isaacs