日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

细胞周期蛋白E诱导的复制压力驱动p53依赖的全基因组复制

Jingkun Zeng, Stephanie A Hills, Eiko Ozono, John F X Diffley

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

核苷酸结合会阻止真核复制解旋酶在激活过程中的扩散。

Daniel Ramírez Montero ,Humberto Sánchez ,Edo van Veen ,Theo van Laar ,Belén Solano ,John F X Diffley ,Nynke H Dekker

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

染色质化的起始点通过相互作用和空间限制降低了ORC和MCM的移动性。

Humberto Sánchez ,Zhaowei Liu ,Edo van Veen ,Theo van Laar ,John F X Diffley ,Nynke H Dekker

DNA replication origins retain mobile licensing proteins

DNA复制起点保留移动许可蛋白

Humberto Sánchez ,Kaley McCluskey ,Theo van Laar ,Edo van Veen ,Filip M Asscher ,Belén Solano ,John F X Diffley ,Nynke H Dekker

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

通过筛选 nsp12/7/8 RNA 依赖性 RNA 聚合酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Agustina P Bertolin #, Florian Weissmann #, Jingkun Zeng #, Viktor Posse, Jennifer C Milligan, Berta Canal, Rachel Ulferts, Mary Wu, Lucy S Drury, Michael Howell, Rupert Beale, John F X Diffley

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

通过筛选 Nsp3 木瓜蛋白酶样蛋白酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Chew Theng Lim #, Kang Wei Tan #, Mary Wu, Rachel Ulferts, Lee A Armstrong, Eiko Ozono, Lucy S Drury, Jennifer C Milligan, Theresa U Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim Labib, John F X Diffley

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

通过筛选 nsp13 解旋酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Jingkun Zeng #, Florian Weissmann #, Agustina P Bertolin #, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F X Diffley

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

通过筛选 nsp15 内切核糖核酸酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Berta Canal #, Ryo Fujisawa #, Allison W McClure #, Tom D Deegan #, Mary Wu, Rachel Ulferts, Florian Weissmann, Lucy S Drury, Agustina P Bertolin, Jingkun Zeng, Rupert Beale, Michael Howell, Karim Labib, John F X Diffley

Multiplex Cell Fate Tracking by Flow Cytometry

通过流式细胞术进行多重细胞命运追踪

Marta Rodríguez-Martínez, Stephanie A Hills, John F X Diffley, Jesper Q Svejstrup

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

DNA-CMG-Pol epsilon 的结构阐明了非催化聚合酶模块在真核复制体中的作用

Panchali Goswami, Ferdos Abid Ali, Max E Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M C Cheung, John F X Diffley, Alessandro Costa