John Gordon相关文献与解析，生知库 | 链接生命科学的每一步

Lakin, Kimberly S; Spivack, John; Gordon, Jessica K; Zhang, Yaxia; Jannat-Khah, Deanna; Ravichandran, Hiranmayi; Anandasabapathy, Niroshana; Orange, Dana E; Spiera, Robert F

系统性硬化症

免疫/内分泌

发表日期：2026

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Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

塞拉宁涂层气管插管降低呼吸机相关性肺炎：一项前瞻性、纵向、交叉、中断时间实施研究（CEASE VAP 研究）

期刊:Critical Care Explorations

影响因子:2.7

doi:10.1097/CCE.0000000000001382

Muscedere, John; Norman, Patrick A; D'Arsigney, Christine; Day, Andrew G; Boyd, John Gordon; Boyd, Tracy; Maslove, David M; Sibley, Stephanie; Shorey, Carrie L

肺炎

发表日期：2026

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Methane emissions reduced using gypsum in pilot-scale dairy manure tanks

在试验规模的奶牛粪便池中使用石膏可减少甲烷排放

期刊:Journal of Environmental Quality

影响因子:2.3

doi:10.1002/jeq2.70112

Tomalty, Emma; Laniel, Mélodie; Leblanc, Vyncent; McKim, Ulrica; Yanni, Sandra; Moher Copa, Patricia; McCabe, John; Gordon, Robert; VanderZaag, Andrew

发表日期：2026

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Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition

抑制急性轴突DLK棕榈酰化具有神经保护作用，并可避免细胞范围DLK抑制的有害影响。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-58036-6

Xiaotian Zhang ，Heykyeong Jeong ，Jingwen Niu ，Sabrina M Holland ，Brittany N Rotanz ，John Gordon ，Margret B Einarson ，Wayne E Childers ，Gareth M Thomas

细胞生物学

发表日期：2025

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Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial

采用健康供体粪便进行粪便微生物移植联合抗PD-1治疗，可提高晚期黑色素瘤患者的生存率：MIMic 1期试验的最终结果

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-012659

Hadi, Danial Khan; Baines, Kelly J; Jabbarizadeh, Behnam; Miller, Wilson H; Jamal, Rahima; Ernst, Scott; Logan, Diane; Belanger, Karl; Esfahani, Khashayar; Elkrief, Arielle; Parvathy, Seema Nair; Silverman, Michael S; Routy, Bertrand; Maleki Vareki, Saman; Lenehan, John Gordon

RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors

RTx-303，一种口服生物利用度高的Polθ聚合酶抑制剂，可增强PARP抑制剂在BRCA突变肿瘤中的疗效

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00551.

Gurushankar Chandramouly ,William Fried ,John Gordon ,Douglas Ralph ,Channita Keuk ,Sangeeta Kumari ,Mercy Ramanjulu ,William Auerbacher ,Leonid Minakhin ,Taylor Tredinnick ,Bernadette Tiberi ,George Morton ,Robert Betsch ,Kathy Q Cai ,Umeshkumar M Vekariya ,Mrityunjay Tyagi ,Tomasz Skorski ,Sergey Karakashev ,Neil Johnson ,Wayne E Childers Jr ,Xiaojiang S Chen ,Richard T Pomerantz

IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers

IMPACT-ICU可行性研究：一项针对重症疾病幸存者及其照护者的后续护理干预的实用性混合方法随机对照试验

期刊:BMJ Open

影响因子:2.3

doi:10.1136/bmjopen-2024-086799

Jawa, Natasha Arianne; Maslove, David M; Sibley, Stephanie; Muscedere, John; Hunt, Miranda; Hanley, Michaela; Boyd, Tracy; Westphal, Robin; Mathur, Sunita; Fakolade, Afolasade; Tryon, Michelle; Boyd, John Gordon

发表日期：2025

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An examination of symptoms, function and quality of life as conjoint clinical outcome domains for treatment-resistant depression

对难治性抑郁症的症状、功能和生活质量作为联合临床结果领域的研究

期刊:

影响因子:

doi:10.1016/j.xjmad.2025.100121

Conway, Charles R; Rush, A John; Gordon, Charles; Preskorn, Sheldon H; Sackeim, Harold A; Aaronson, Scott T; McIntyre, Roger S; Lee, Ying-Chieh Lisa; Shy, Olivia; Tran, Quyen; Way, Jeffrey; Bunker, Mark T

Contextual factors of implementing APOL1 genetic testing into living kidney donor clinical evaluation

将APOL1基因检测纳入活体肾脏捐献者临床评估的背景因素

期刊:

影响因子:

doi:10.1007/s00103-025-04068-8

Merle, James L; Kuo, Marissa C; Gacki-Smith, Jessica; Agrawal, Akansha; Friedewald, John; Gordon, Elisa J; Smith, Justin D

APOL1

发表日期：2025

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Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

发现一种小分子抑制剂，该抑制剂能将Polθ捕获在DNA上，并与PARP抑制剂产生协同作用。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-46593-1

William Fried # ,Mrityunjay Tyagi # ,Leonid Minakhin ,Gurushankar Chandramouly ,Taylor Tredinnick ,Mercy Ramanjulu ,William Auerbacher ,Marissa Calbert ,Timur Rusanov ,Trung Hoang ,Nikita Borisonnik ,Robert Betsch ,John J Krais ,Yifan Wang ,Umeshkumar M Vekariya ,John Gordon ,George Morton ,Tatiana Kent ,Tomasz Skorski ,Neil Johnson ,Wayne Childers ,Xiaojiang S Chen ,Richard T Pomerantz

PARP

发表日期：2024

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Skin Biopsies Enhance Prediction of Clinical Trajectory in Diffuse Cutaneous Systemic Sclerosis

皮肤活检可提高弥漫性皮肤系统性硬化症临床病程的预测准确性

Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

塞拉宁涂层气管插管降低呼吸机相关性肺炎：一项前瞻性、纵向、交叉、中断时间实施研究（CEASE VAP 研究）

Methane emissions reduced using gypsum in pilot-scale dairy manure tanks

在试验规模的奶牛粪便池中使用石膏可减少甲烷排放

Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition

抑制急性轴突DLK棕榈酰化具有神经保护作用，并可避免细胞范围DLK抑制的有害影响。

Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial

采用健康供体粪便进行粪便微生物移植联合抗PD-1治疗，可提高晚期黑色素瘤患者的生存率：MIMic 1期试验的最终结果

RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors

RTx-303，一种口服生物利用度高的Polθ聚合酶抑制剂，可增强PARP抑制剂在BRCA突变肿瘤中的疗效

IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers

IMPACT-ICU可行性研究：一项针对重症疾病幸存者及其照护者的后续护理干预的实用性混合方法随机对照试验

An examination of symptoms, function and quality of life as conjoint clinical outcome domains for treatment-resistant depression

对难治性抑郁症的症状、功能和生活质量作为联合临床结果领域的研究

Contextual factors of implementing APOL1 genetic testing into living kidney donor clinical evaluation

将APOL1基因检测纳入活体肾脏捐献者临床评估的背景因素

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

发现一种小分子抑制剂，该抑制剂能将Polθ捕获在DNA上，并与PARP抑制剂产生协同作用。