日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

CDK8 抑制的转录拮抗作用可提高 MEK 抑制剂的治疗效果

Clare F Malone #, Minjee Kim #, Gabriela Alexe, Kathleen Engel, Alexandra B Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M Hatcher, Nathanael S Gray, Federica Piccioni, Kimberly Stegmaier

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

CDK8 在 BCR-ABL1+ 白血病中发挥激酶非依赖性作用

Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M Knab, Iris Z Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M Hatcher, Yanke Liang, Nicholas P Kwiatkowski, Daniela Fux, Andrea

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

SRPKIN-1:一种共价 SRPK1/2 抑制剂,可有效将 VEGF 从促血管生成异构体转化为抗血管生成异构体

John M Hatcher, Guowei Wu, Chuyue Zeng, Jie Zhu, Fan Meng, Sherrina Patel, Wenqiu Wang, Scott B Ficarro, Alan L Leggett, Chelsea E Powell, Jarrod A Marto, Kang Zhang, Jacky Chi Ki Ngo, Xiang-Dong Fu, Tinghu Zhang, Nathanael S Gray

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

高效选择性类固醇 CDK8 抑制剂和降解剂的开发

John M Hatcher, Eric S Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim, Nathanael S Gray

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

发现吡咯并嘧啶 (JH-II-127),一种高效、选择性且可渗透大脑的 LRRK2 抑制剂

John M Hatcher, Jinwei Zhang, Hwan Geun Choi, Genta Ito, Dario R Alessi, Nathanael S Gray