日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation

PARP2活性位点螺旋解开,从而允许DNA损伤诱导的酶激活。

Emily S Smith-Pillet ,Ramya Billur ,Marie-France Langelier ,Tanaji T Talele ,John M Pascal ,Ben E Black

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

PARP 抑制剂 veliparib 的新修饰可增强 PARP1 与 DNA 断裂的结合

Uday Kiran Velagapudi #, Élise Rouleau-Turcotte #, Ramya Billur #, Xuwei Shao, Manisha Patil, Ben E Black, John M Pascal, Tanaji T Talele

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP

PARP4/vault PARP 的 PARP1 同源区域的结构和生化分析

Léonie Frigon, John M Pascal

PARP1 associates with R-loops to promote their resolution and genome stability

PARP1与R环关联,以促进其分辨率和基因组稳定性

Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Henry Bannister, Hai Dang Nguyen, Caroline Curry, John M Pascal, Guy G Poirier, Hong Wang, Jean-Yves Masson, Elise Fouquerel

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

PARP抑制剂控制PARP1-DNA保留的两步机制

Huijun Xue,Amit Bhardwaj,Yandong Yin,Carel Fijen,Anastasiya Ephstein,Lianglin Zhang,Xia Ding,John M Pascal,Todd L VanArsdale,Eli Rothenberg

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

DNA 结合和靶标停留时间的变构调节驱动基于酞嗪酮的 PARP-1 抑制剂的细胞毒性

Moriah R Arnold, Marie-France Langelier, Jessica Gartrell, Ilsa T Kirby, Daniel J Sanderson, Daniel S Bejan, Justina Šileikytė, Sunil K Sundalam, Shanthi Nagarajan, Parthiban Marimuthu, Anna K Duell, Anang A Shelat, John M Pascal, Michael S Cohen

Unorthodox PCNA Binding by Chromatin Assembly Factor 1

染色质组装因子 1 与 PCNA 的非常规结合

Amogh Gopinathan Nair, Nick Rabas, Sara Lejon, Caleb Homiski, Michael J Osborne, Normand Cyr, Aleksandr Sverzhinsky, Thomas Melendy, John M Pascal, Ernest D Laue, Katherine L B Borden, James G Omichinski, Alain Verreault

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

人类 PARP1 通过 Pol II 进行核小体和组蛋白置换促进转录

Elena Y Kotova, Fu-Kai Hsieh, Han-Wen Chang, Natalia V Maluchenko, Marie-France Langelier, John M Pascal, Donal S Luse, Alexey V Feofanov, Vasily M Studitsky

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

PARP-1 的 HD 调节子域的动力学;PARP 激活和抑制中的底物进入和变构

Tom E H Ogden, Ji-Chun Yang, Marianne Schimpl, Laura E Easton, Elizabeth Underwood, Philip B Rawlins, Michael M McCauley, Marie-France Langelier, John M Pascal, Kevin J Embrey, David Neuhaus

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

BRCT-BRCT 与 XRCC1 支架蛋白的非典型相互作用将人类 DNA 连接酶 IIIα 压缩在灵活的 DNA 修复复合物中

Michal Hammel, Ishtiaque Rashid, Aleksandr Sverzhinsky, Yasin Pourfarjam, Miaw-Sheue Tsai, Tom Ellenberger, John M Pascal, In-Kwon Kim, John A Tainer, Alan E Tomkinson