Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors
DNA 结合和靶标停留时间的变构调节驱动基于酞嗪酮的 PARP-1 抑制剂的细胞毒性
期刊:Cell Chemical Biology
影响因子:6.6
doi:10.1016/j.chembiol.2022.11.006
Moriah R Arnold, Marie-France Langelier, Jessica Gartrell, Ilsa T Kirby, Daniel J Sanderson, Daniel S Bejan, Justina Šileikytė, Sunil K Sundalam, Shanthi Nagarajan, Parthiban Marimuthu, Anna K Duell, Anang A Shelat, John M Pascal, Michael S Cohen