日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C 抑制可逆转 SARS-CoV-2 引起的自噬通量受损

Karim Marwah, Mishra Manjari, Lo Chieh-Wen, Saul Sirle, Cagirici Halise Busra, Gourdelier Manon, Ghita Luca, Ojha Amrita, Tran Do Hoang Nhu, Agrawal Aditi, McGraw Connor, East Michael P, Gammeltoft Karen Anbro, Sahoo Malaya Kumar, Mooney Nancie A, Johnson Gary L, Das Soumita, Leyssen Pieter, Neyts Johan, Chiu Winston, Cohen Courtney A, Bukh Jens, Gottwein Judith, Dye John M, Neff Norma, Jackson Peter K, Pinsky Benjamin A, Laitinen Tuomo, Pantsar Tatu, Poso Antti, Zanini Fabio, De Jonghe Steven, Asquith Christopher R M, Einav Shirit

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

通过表征 EGFRvIII 驱动的胶质母细胞瘤的适应性激酶组重编程,识别和利用组合合成致死性

Lin, Benjamin; Shelton, Abigail K; Smithberger, Erin; Ziebro, Julia; Skinner, Kasey R; Bash, Ryan E; Kirkman, Richard; Stamper, Allie; Butler, Madison; Flores, Alex; Angus, Steven P; East, Michael P; Cloughesy, Timothy F; Nathanson, David A; Berens, Michael E; Sarkaria, Jann N; Binder, Zev A; O'Rourke, Donald M; Howton, Timothy C; Lasseigne, Brittany N; Willey, Christopher D; Johnson, Gary L; Hjelmeland, Anita B; Furnari, Frank B; Miller, C Ryan

Kinome Reprogramming of G2/M Kinases and Repression of MYCN Contribute to Superior Efficacy of Lorlatinib in ALK-Driven Neuroblastoma.

G2/M期激酶的激酶组重编程和MYCN的抑制有助于洛拉替尼在ALK驱动的神经母细胞瘤中发挥更优异的疗效

Matkar Smita, East Michael P, Stuhlmiller Timothy J, Witek Gabriela M, Farrel Alvin, Pastor Steven, Okumu Denis O, Kennedy Anne, Kalna Joshua R, Berko Esther R, Casey Colleen E, Krytska Kateryna, Patel Khushbu, Rokita Jo Lynne, Gerelus Mark, Maris John M, Johnson Gary L, Mossé Yael P

Phase II study of MEK inhibitor trametinib alone and in combination with AKT inhibitor GSK2141795/uprosertib in patients with metastatic triple negative breast cancer

一项针对转移性三阴性乳腺癌患者的MEK抑制剂曲美替尼单药治疗及联合AKT抑制剂GSK2141795/uprosertib治疗的II期研究

Prasath, Vishnu; Boutrid, Hinda; Wesolowski, Robert; Abdel-Rasoul, Mahmoud; Timmers, Cynthia; Lustberg, Maryam; Layman, Rachel M; Macrae, Erin; Mrozek, Ewa; Shapiro, Charles; Glover, Kristyn; Vater, Mark; Budd, G Thomas; Harris, Lyndsay; Isaacs, Claudine; Dees, Claire; Perou, Charles M; Johnson, Gary L; Poklepovic, Andrew; Chen, Helen; Villalona-Calero, Miguel; Carson, William; Stover, Daniel G; Ramaswamy, Bhuvaneswari

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

MEK抑制剂曲美替尼可导致小鼠心脏线粒体损伤并诱导先天免疫反应

Fisher-Wellman, Kelsey H; Lutze, Richard D; Kirkland, Logan G; Beak, Ju Youn; Morrissey, Samantha M; Sandroni, Peyton B; Huang, Wei; Bailon, Julian D; Schroder, Melissa A; Albrecht, Lars A; Goyal, Mansi; Chin, Andrew L; Green, Thomas D; McClung, Joseph M; Montgomery, McLane M; Hagen, James T; Chrest, Brett R; Zawistowski, Jon S; Stuhlmiller, Timothy J; Gomez, Shawn M; Prathumsap, Nanthip; Zhang, Qing; Zhang, Jing; Xu, Weiyi; Zhang, Lilei; Meier, Jeremy A; Carey, Lisa A; Schisler, Jonathan C; Johnson, Gary L; Jensen, Brian C

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer.

凡德他尼诱导的激酶可塑性增强了雌激素受体阳性乳腺癌对三苯氧胺的敏感性

Kakati Rasha T, Whitman Austin A, Haase Santiago, Szenasi Attila T, Thai Christine Hnc, Brunk Elizabeth, Okumu Denis O, East Michael P, Perou Charles M, Johnson Gary L, Spanheimer Philip M

Illuminating function of the understudied druggable kinome

揭示鲜为人知的可成药激酶组的关键功能

Gomez, Shawn M; Axtman, Alison D; Willson, Timothy M; Major, Michael B; Townsend, Reid R; Sorger, Peter K; Johnson, Gary L

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

利用定量构效关系发现和优化窄谱Tousled样激酶2 (TLK2) 抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Kinome state is predictive of cell viability in pancreatic cancer tumor and cancer-associated fibroblast cell lines.

激酶组状态可预测胰腺癌肿瘤和癌症相关成纤维细胞系的细胞活力

Berginski Matthew E, Jenner Madison R, Joisa Chinmaya U, Herrera Loeza Gabriela, Golitz Brian T, Lipner Matthew B, Leary Jack R, Rashid Naim, Johnson Gary L, Yeh Jen Jen, Gomez Shawn M

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

利用定量构效关系发现和优化Tousled样激酶2(TLK2)的窄谱抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L