日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy

回复:降低小胶质细胞APOE表达的定量性状基因座与脑淀粉样血管病减少相关

Shade, Lincoln M P; Qiao, Qi; Katsumata, Yuriko; Mukherjee, Shubhabrata; Broome, Jai G; Johnson, Lance A; Ebbert, Mark T W; Nelson, Peter T; Fardo, David W

Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA

lecanemab相关ARIA中细胞毒性CD8⁺ T细胞的克隆扩增

Johnson, Lance A; Saito, Kai; Pallerla, Akhil V; Funnell, Jessica L; Ezzo, Ashley R; Song, Chelsea M; Harrison, Douglas A; Norton, Noah J; Moore, Lauren C; Van Eldik, Linda J; Fardo, David W; Cooper, Greg E; Morganti, Josh M

Real-Time In Vivo Detection of Nanocarrier Number and Velocity in the Cerebrovasculature Using Hot Band Absorption

利用热带吸收法实时体内检测脑血管中纳米载体的数量和速度

Wang, Xiaojin; Liisberg, Mikkel B; Rück, Vanessa; Pande, Sagar; Nolt, Georgia L; Li, Lan; Yin, Qianye; Harvey, Brock T; Nagel, Julia; Fu, Xu; Johnson, Lance A; Vosch, Tom; Richards, Christopher I

Protocol for stable isotope tracing of primary human peripheral blood mononuclear cells

人外周血单核细胞稳定同位素示踪方案

Hart, Samantha N; Williams, Holden; Inabnet, William B 3rd; Steiner, Joshua P; Jain, Varun; Kern, Philip A; Wood, Cecily R; Nikolajczyk, Barbara S; Johnson, Lance A

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

Tau蛋白病理改变会重编程葡萄糖代谢,从而导致皮质过度兴奋、兴奋/抑制失衡和睡眠障碍。

Irmen, Riley E; Turner, Sierra M; Snipes, J Andy; Schloss, Kaelyn H; Wang, Xiaodan; Williams, Holden C; Velmurugan, Gopal V; Hunt, Jerry B Jr; Li, Junyan; Sullivan, Patrick G; Lee, Daniel C; Bauer, Adam Q; Johnson, Lance A; Macauley, Shannon L

APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.

小鼠中 APOE4 到 APOE2 等位基因转换可改善阿尔茨海默病相关的代谢特征、神经病理学和认知能力。

Golden Lesley R, Siano Dahlia S, Stephens Isaiah O, MacLean Steven M, Saito Kai, Nolt Georgia L, Funnell Jessica L, Pallerla Akhil V, Lee Sangderk, Smith Cathryn, Chen Jing, Zhu Haining, Voy Clairity, Whitus Callie M, Hernandez Gabriela, Farmer Brandon C, Pandya Kumar, Cowley Dale O, Macauley Shannon L, Gordon Scott M, Morganti Josh M, Johnson Lance A

Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4.

即使在存在内源性 APOE4 的情况下,小胶质细胞衍生的 APOE2 也能改善髓鞘再生。

Nolt Georgia L, Golden Lesley R, Thorpe Shealee P, Funnell Jessica L, Stephens Isaiah O, Hernandez Gabriela, MacLean Steven M, Lucido Chloe C, Brock Chesney R, Pallerla Akhil V, Adreon Darcy R, Williams Holden C, Morganti Josh M, Johnson Lance A

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

ATP敏感性钾通道通过改变糖酵解通量来调节皮层活动和睡眠

Constantino, Nicholas J; Carroll, Caitlin M; Williams, Holden C; Vekaria, Hemendra J; Yuede, Carla M; Saito, Kai; Sheehan, Patrick W; Snipes, J Andy; Raichle, Marcus E; Musiek, Erik S; Sullivan, Patrick G; Morganti, Josh M; Johnson, Lance A; Macauley, Shannon L

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

APOE4 重塑脂滴蛋白质组并调节小胶质细胞炎症反应

Friday, Cassi M; Stephens, Isaiah O; Smith, Cathryn T; Lee, Sangderk; Satish, Diksha; Devanney, Nicholas A; Cohen, Sarah; Morganti, Josh M; Gordon, Scott M; Johnson, Lance A

Knockout of Perilipin-2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli

敲除小胶质细胞中的Perilipin-2会改变脂滴的积累和对阿尔茨海默病刺激的反应

Stephens, Isaiah O; Johnson, Lance A