日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The cellular esterase FrmB controls metabolic homeostasis and small colony variant formation in Staphylococcus aureus

细胞酯酶FrmB控制金黄色葡萄球菌的代谢稳态和小菌落变异体的形成

O'Brien, Kelsey A; Miller, Justin J; Johnson, R Jeremy; Hoops, Geoffrey C; John, Audrey R Odom

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

疟原虫体内前药的激活是由一种输入的红细胞酯酶——酰基肽水解酶(APEH)介导的。

Sundararaman, Sesh A; Miller, Justin J; Daley, Ellora C; O'Brien, Kelsey A; Kasak, Paulina; Daniels, Abigail M; Edwards, Rachel L; Heidel, Kenneth M; Bague, Darean A; Wilson, Madeleine A; Koelper, Andrew J; Kourtoglou, Elexi C; White, Alex D; August, Sloan A; Apple, Georgia A; Rouamba, Regis W; Durand, Anthony J; Esteb, John J; Muller, Florian L; Johnson, R Jeremy; Hoops, Geoffrey C; Dowd, Cynthia S; Odom John, Audrey R

Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs

更正:抗葡萄球菌前药的结构导向微生物靶向治疗

Miller, Justin J; Shah, Ishaan T; Hatten, Jayda; Barekatain, Yasaman; Mueller, Elizabeth A; Moustafa, Ahmed M; Edwards, Rachel L; Dowd, Cynthia S; Hoops, Geoffrey C; Johnson, R Jeremy; Planet, Paul; Muller, Florian L; Jez, Joseph; Odom John, Audrey R

Transition metal cation inhibition of Mycobacterium tuberculosis esterase RV0045C.

过渡金属阳离子对结核分枝杆菌酯酶RV0045C的抑制作用

Bowles Isobel E, Pool Emily H, Lancaster Benjamin S, Lawson Emily K, Savas Christopher P, Kartje Zach J, Severinac Luke, Cho David H, Macbeth Mark R, Johnson R Jeremy, Hoops Geoffrey C

Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance

微生物酯酶与酯类前药:对抗抗生素耐药性的意想不到的结合

Larsen, Erik M; Johnson, R Jeremy

Fluorogenic structure activity library pinpoints molecular variations in substrate specificity of structurally homologous esterases

荧光结构活性库可精确定位结构同源酯酶底物特异性的分子变异

White, Alex; Koelper, Andrew; Russell, Arielle; Larsen, Erik M; Kim, Charles; Lavis, Luke D; Hoops, Geoffrey C; Johnson, R Jeremy

Measuring the Global Substrate Specificity of Mycobacterial Serine Hydrolases Using a Library of Fluorogenic Ester Substrates

利用荧光酯底物库测定分枝杆菌丝氨酸水解酶的全局底物特异性

Bassett, Braden; Waibel, Brent; White, Alex; Hansen, Heather; Stephens, Dominique; Koelper, Andrew; Larsen, Erik M; Kim, Charles; Glanzer, Adam; Lavis, Luke D; Hoops, Geoffrey C; Johnson, R Jeremy

In Vivo Delivery and Activation of Masked Fluorogenic Hydrolase Substrates by Endogenous Hydrolases in C. elegans

秀丽隐杆线虫体内内源性水解酶对掩蔽荧光水解酶底物的体内递送和激活

Dube, Shataakshi; Dube, Hitesh; Green, Nicole B; Larsen, Erik M; White, Alex; Johnson, R Jeremy; Kowalski, Jennifer R

Ester-prodrugs of ethambutol control its antibacterial activity and provide rapid screening for mycobacterial hydrolase activity

乙胺丁醇酯类前药可控制其抗菌活性,并可用于快速筛选分枝杆菌水解酶活性。

Larsen, Erik M; Stephens, Dominique C; Clarke, Nathan H; Johnson, R Jeremy

The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis.

来自剧毒细菌土拉弗朗西斯菌的毒力相关丝氨酸水解酶的异常底物特异性

Farberg Alexander M, Hart Whitney K, Johnson R Jeremy