日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

利用大规模基因组数据,对C9orf72相关ALS/FTD药物进行无机制的重新定位

Sara Saez-Atienzar ,Cleide Dos Santos Souza ,Ruth Chia ,Selina N Beal ,Ileana Lorenzini ,Ruili Huang ,Jennifer Levy ,Camelia Burciu ,Jinhui Ding ,J Raphael Gibbs ,Ashley Jones ,Ramita Dewan ,Viviana Pensato ,Silvia Peverelli ,Lucia Corrado ,Joke J F A van Vugt ,Wouter van Rheenen ,Ceren Tunca ,Elif Bayraktar ,Menghang Xia ,Aleksey Shatunov ,Cinzia Tiloca ,Nicola Ticozzi ,Federico Verde ,Letizia Mazzini ,Kevin Kenna ,Ahmad Al Khleifat ,Sarah Opie-Martin ,Flavia Raggi ,Massimiliano Filosto ,Stefano Cotti Piccinelli ,Alessandro Padovani ,Stella Gagliardi ,Maurizio Inghilleri ,Alessandra Ferlini ,Rosario Vasta ,Andrea Calvo ,Cristina Moglia ,Antonio Canosa ,Umberto Manera ,Maurizio Grassano ,Jessica Mandrioli ,Gabriele Mora ,Christian Lunetta ,Raffaella Tanel ,Francesca Trojsi ,Patrizio Cardinali ,Salvatore Gallone ,Maura Brunetti ,Daniela Galimberti ,Maria Serpente ,Chiara Fenoglio ,Elio Scarpini ,Giacomo P Comi ,Stefania Corti ,Roberto Del Bo ,Mauro Ceroni ,Giuseppe Lauria Pinter ,Franco Taroni ,Eleonora Dalla Bella ,Enrica Bersano ,Charles J Curtis ,Sang Hyuck Lee ,Raymond Chung ,Hamel Patel ,Karen E Morrison ,Johnathan Cooper-Knock ,Pamela J Shaw ,Gerome Breen ,Richard J B Dobson ,Clifton L Dalgard ,Ammar Al-Chalabi ,Leonard H van den Berg ,Russell McLaughlin ,Orla Hardiman ,Cristina Cereda ,Gianni Sorarù ,Sandra D'Alfonso ,Siddharthan Chandran ,Suvankar Pal ,Antonia Ratti ,Cinzia Gellera ,Kory Johnson ,Tara Doucet-O'Hare ,Nicholas Pasternack ,Tongguang Wang ,Avindra Nath ,Gabriele Siciliano ,Vincenzo Silani ,Ayşe Nazlı Başak ,Jan H Veldink ,William Camu ,Jonathan D Glass ,John E Landers ,Adriano Chiò ,Rita Sattler ,Christopher E Shaw ,Laura Ferraiuolo ,Isabella Fogh ,Bryan J Traynor

Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains

隐秘外显子包含是衰老大脑中 LATE-NC 的分子特征

Mingee Chung, E Kathleen Carter, Austin M Veire, Eric B Dammer, Jianjun Chang, Duc M Duong, Nisha Raj, Gary J Bassell, Jonathan D Glass, Tania F Gendron, Peter T Nelson, Allan I Levey, Nicholas T Seyfried, Zachary T McEachin

pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

pTDP-43 水平与 C9orf72 ALS/FTD 患者前额皮质中细胞类型特异性分子改变相关

Hsiao-Lin V Wang, Jian-Feng Xiang, Chenyang Yuan, Austin M Veire, Tania F Gendron, Melissa E Murray, Malú G Tansey, Jian Hu, Marla Gearing, Jonathan D Glass, Peng Jin, Victor G Corces, Zachary T McEachin

Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles

面向神经退行性疾病分期的通用机器学习工作流程,重点关注神经原纤维缠结

Juan C Vizcarra, Thomas M Pearce, Brittany N Dugger, Michael J Keiser, Marla Gearing, John F Crary, Evan J Kiely, Meaghan Morris, Bartholomew White, Jonathan D Glass, Kurt Farrell, David A Gutman

ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function

与肌萎缩侧索硬化症 (ALS) 相关的 KIF5A ΔExon27 突变体通过功能获得性突变导致神经元毒性。

Devesh C Pant # ,Janani Parameswaran # ,Lu Rao ,Isabel Loss ,Ganesh Chilukuri ,Rosanna Parlato ,Liang Shi ,Jonathan D Glass ,Gary J Bassell ,Philipp Koch ,Rüstem Yilmaz ,Jochen H Weishaupt ,Arne Gennerich ,Jie Jiang

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

综合蛋白质组学揭示无症状和有症状阿尔茨海默病的脑脊液生物标志物

Lenora Higginbotham, Lingyan Ping, Eric B Dammer, Duc M Duong, Maotian Zhou, Marla Gearing, Cheyenne Hurst, Jonathan D Glass, Stewart A Factor, Erik C B Johnson, Ihab Hajjar, James J Lah, Allan I Levey, Nicholas T Seyfried

Longitudinal biomarkers in amyotrophic lateral sclerosis

肌萎缩侧索硬化症的纵向生物标志物

Fen Huang, Yuda Zhu, Jennifer Hsiao-Nakamoto, Xinyan Tang, Jason C Dugas, Miriam Moscovitch-Lopatin, Jonathan D Glass, Robert H Brown Jr, Shafeeq S Ladha, David Lacomis, Jeffrey M Harris, Kimberly Scearce-Levie, Carole Ho, Robert Bowser, James D Berry

A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain

跨 ALS-FTD 疾病谱的蛋白质组学网络方法可解决人类大脑的临床表型和遗传脆弱性

Mfon E Umoh, Eric B Dammer, Jingting Dai, Duc M Duong, James J Lah, Allan I Levey, Marla Gearing, Jonathan D Glass, Nicholas T Seyfried

Loss of dopamine phenotype among midbrain neurons in Lesch-Nyhan disease

莱施-尼汉病中脑神经元多巴胺表型的丧失

Martin Göttle, Cecilia N Prudente, Rong Fu, Diane Sutcliffe, Hong Pang, Deborah Cooper, Emir Veledar, Jonathan D Glass, Marla Gearing, Jasper E Visser, H A Jinnah

Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease

阿尔茨海默病中的小核糖核酸 (snRNA) 聚集体

Chadwick M Hales, Eric B Dammer, Ian Diner, Hong Yi, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Thomas J Montine, Allan I Levey, James J Lah