日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

主要 TMEM106B 痴呆风险等位基因影响衰老人类海马中的 TMEM106B 蛋白水平、纤维形成和髓鞘脂质稳态

Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T Sutherland, Mark Larance, Anthony S Don

Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

髓鞘脂质代谢紊乱可区分由 GRN 和 C9orf72 基因突变引起的额颞叶痴呆

Oana C Marian, Jonathan D Teo, Jun Yup Lee, Huitong Song, John B Kwok, Ramon Landin-Romero, Glenda Halliday, Anthony S Don

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

小鼠少突胶质细胞中极长链神经酰胺合成缺陷导致的早期小胶质细胞反应、髓鞘退化和死亡

Jonathan D Teo ,Oana C Marian ,Alanna G Spiteri ,Madeline Nicholson ,Huitong Song ,Jasmine X Y Khor ,Holly P McEwen ,Anjie Ge ,Monokesh K Sen ,Laura Piccio ,Jessica L Fletcher ,Nicholas J C King ,Simon S Murray ,Jens C Brüning ,Anthony S Don

Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein

鞘氨醇激酶 2 的消融可通过下调神经酰胺转移蛋白来抑制脂肪肝相关的肝细胞癌

Xin Tracy Liu #, Long Hoa Chung #, Da Liu, Jinbiao Chen, Yu Huang, Jonathan D Teo, Xingxing Daisy Han, Yinan Zhao, Fiona H X Guan, Collin Tran, Jun Yup Lee, Timothy A Couttas, Ken Liu, Geoffery W McCaughan, Mark D Gorrell, Anthony S Don, Shubiao Zhang, Yanfei Qi

Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

鞘氨醇激酶 2 对铜宗中毒后的髓鞘再生至关重要

Huitong Song, Holly P McEwen, Thomas Duncan, Jun Yup Lee, Jonathan D Teo, Anthony S Don

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes

鞘氨醇 1-磷酸酯而非芬戈莫德可通过诱导星形胶质细胞中的神经营养基因表达来保护神经元免于兴奋毒性细胞死亡

Collin Tran, Benjamin Heng, Jonathan D Teo, Sean J Humphrey, Yanfei Qi, Timothy A Couttas, Holly Stefen, Merryn Brettle, Thomas Fath, Gilles J Guillemin, Anthony S Don

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease

鞘氨醇激酶2可增强淀粉样蛋白沉积,但在阿尔茨海默病小鼠模型中可防止海马体积减少和脱髓鞘。

Mona Lei ,Jonathan D Teo ,Huitong Song ,Holly P McEwen ,Jun Yup Lee ,Timothy A Couttas ,Thomas Duncan ,Rose Chesworth ,Josefine Bertz ,Magdalena Przybyla ,Janet Van Eersel ,Benjamin Heng ,Gilles J Guillemin ,Lars M Ittner ,Thomas Fath ,Brett Garner ,Arne Ittner ,Tim Karl ,Anthony S Don

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

神经酰胺合酶 1 的选择性抑制剂揭示了其在脂肪代谢中的新作用

Nigel Turner, Xin Ying Lim, Hamish D Toop, Brenna Osborne, Amanda E Brandon, Elysha N Taylor, Corrine E Fiveash, Hemna Govindaraju, Jonathan D Teo, Holly P McEwen, Timothy A Couttas, Stephen M Butler, Abhirup Das, Greg M Kowalski, Clinton R Bruce, Kyle L Hoehn, Thomas Fath, Carsten Schmitz-Peiffer,