日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism-based inactivation of human aldehyde oxidase by erlotinib: Mechanistic insights from structural analogs and molecular docking

厄洛替尼对人醛氧化酶的机制性失活:来自结构类似物和分子对接的机制性见解

Kweh, Jia Rong; Ng, Nicholas Kai Ming; Ngoh, Le Min; Li, Cynthia Jing Yan; Tan, Bao Jie; Tan, Wee Kiat; Mettu, Vijaya Saradhi; Austin-Muttitt, Karl; Mullins, Jonathan G L; Lau, Aik Jiang

Computational structural studies of SGLT2-related polypharmacy

SGLT2相关多药的计算结构研究

Lloyd, Aled; Austin-Muttitt, Karl; Mullins, Jonathan G L

In silico drug repurposing at the cytoplasmic surface of human aquaporin 1

利用计算机模拟方法对人水通道蛋白1的细胞质表面进行药物重定位

Lloyd, Aled R; Austin-Muttitt, Karl; Mullins, Jonathan G L

PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice

PDE4B 错义变异增加小鼠对创伤后应激障碍相关表型的易感性

Tatiana V Lipina, Shupeng Li, Ekaterina S Petrova, Tamara G Amstislavskaya, Ryan T Cameron, Christina Elliott, Yoichi Gondo, Alexander McGirr, Jonathan G L Mullins, George S Baillie, James R Woodgett, Steven J Clapcote

PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies

PDZD8基因缺失会导致人类、小鼠和果蝇的认知障碍

Al-Amri, Ahmed H; Armstrong, Paul; Amici, Mascia; Ligneul, Clemence; Rouse, James; El-Asrag, Mohammed E; Pantiru, Andreea; Vancollie, Valerie E; Ng, Hannah W Y; Ogbeta, Jennifer A; Goodchild, Kirstie; Ellegood, Jacob; Lelliott, Christopher J; Mullins, Jonathan G L; Bretman, Amanda; Al-Ali, Ruslan; Beetz, Christian; Al-Gazali, Lihadh; Al Shamsi, Aisha; Lerch, Jason P; Mellor, Jack R; Al Sayegh, Abeer; Ali, Manir; Inglehearn, Chris F; Clapcote, Steven J

Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity

能够驱动细菌细胞色素 P450 单加氧酶活性的病毒编码黄素蛋白的表征

David C Lamb, Jared V Goldstone, Bin Zhao, Li Lei, Jonathan G L Mullins, Michael J Allen, Steven L Kelly, John J Stegeman

Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins

角鲨烯合酶的双膦酸盐抑制剂可保护细胞免受胆固醇依赖性细胞溶解素的侵害

Pospiech, Mateusz; Owens, Siân E; Miller, David J; Austin-Muttitt, Karl; Mullins, Jonathan G L; Cronin, James G; Allemann, Rudolf K; Sheldon, I Martin

Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates

Smith-Lemli-Opitz综合征中胆汁酸生物合成绕过胆固醇:途径中间体的潜在重要性

Abdel-Khalik, Jonas; Hearn, Thomas; Dickson, Alison L; Crick, Peter J; Yutuc, Eylan; Austin-Muttitt, Karl; Bigger, Brian W; Morris, Andrew A; Shackleton, Cedric H; Clayton, Peter T; Iida, Takashi; Sircar, Ria; Rohatgi, Rajat; Marschall, Hanns-Ulrich; Sjövall, Jan; Björkhem, Ingemar; Mullins, Jonathan G L; Griffiths, William J; Wang, Yuqin

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

GRIN1基因的新生突变会导致广泛的双侧多小脑回畸形

Fry Andrew E, Fawcett Katherine A, Zelnik Nathanel, Yuan Hongjie, Thompson Belinda A N, Shemer-Meiri Lilach, Cushion Thomas D, Mugalaasi Hood, Sims David, Stoodley Neil, Chung Seo-Kyung, Rees Mark I, Patel Chirag V, Brueton Louise A, Layet Valérie, Giuliano Fabienne, Kerr Michael P, Banne Ehud, Meiner Vardiella, Lerman-Sagie Tally, Helbig Katherine L, Kofman Laura H, Knight Kristin M, Chen Wenjuan, Kannan Varun, Hu Chun, Kusumoto Hirofumi, Zhang Jin, Swanger Sharon A, Shaulsky Gil H, Mirzaa Ghayda M, Muir Alison M, Mefford Heather C, Dobyns William B, Mackenzie Amanda B, Mullins Jonathan G L, Lemke Johannes R, Bahi-Buisson Nadia, Traynelis Stephen F, Iago Heledd F, Pilz Daniela T

Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation

复发性 TUBA1A p.(Arg2His) 突变的临床和功能特征

Jennifer F Gardner, Thomas D Cushion, Georgios Niotakis, Heather E Olson, P Ellen Grant, Richard H Scott, Neil Stoodley, Julie S Cohen, Sakkubai Naidu, Tania Attie-Bitach, Maryse Bonnières, Lucile Boutaud, Férechté Encha-Razavi, Sheila M Palmer-Smith, Hood Mugalaasi, Jonathan G L Mullins, Daniela T