日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons

长期低 NMNAT2 表达导致亚致死 SARM1 激活和轴突对烟酰胺核苷的反应改变

Christina Antoniou, Andrea Loreto, Jonathan Gilley, Elisa Merlini, Giuseppe Orsomando, Michael P Coleman

NMNAT2 is a druggable target to drive neuronal NAD production

NMNAT2 是驱动神经元 NAD 产生的可用药物靶点

James R Tribble #, Melissa Jöe #, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E Wheelock, Gauti Jóhannesson, Raymond C B Wong, Michael P Coleman, Andrea Brancale, Pete A Williams

Adaptation of a Commercial NAD+ Quantification Kit to Assay the Base-Exchange Activity and Substrate Preferences of SARM1

使用商用 NAD+ 定量试剂盒测定 SARM1 的碱基交换活性和底物偏好

Ilenia Cirilli, Adolfo Amici, Jonathan Gilley, Michael P Coleman, Giuseppe Orsomando

The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

NAD+ 前体 NMN 激活 dSarm 引发果蝇轴突变性

Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Giulia Perillo, Massimiliano Gasparrini, Lucia Cialabrini, Nadia Raffaelli, Carlo Angeletti, Giuseppe Orsomando, Pei-Hsuan Wu, Michael P Coleman, Andrea Loreto, Lukas Jakob Neukomm

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

SARM1 是一种多功能 NAD(P) 酶,具有显著的碱基交换活性,全部受多种生理相关的 NAD 代谢物的调节

Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G Trapanotto, Christina Antoniou, Elisa Merlini, Michael P Coleman, Giuseppe Orsomando

Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival

人类 SARM1 的天然变体会导致内在和显性功能丧失,从而影响轴突存活

Mirlinda Ademi, Xiuna Yang, Michael P Coleman, Jonathan Gilley

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

反义寡核苷酸延迟程序性轴突变性后 Sarm1 单倍体不足或低表达水平

Stacey Anne Gould, Jonathan Gilley, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Michael Coleman

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

神经毒素介导轴突变性调节剂 SARM1 的强效激活

Andrea Loreto #, Carlo Angeletti #, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Elisa Merlini, Peter Arthur-Farraj, Adolfo Amici, Zhenyao Luo, Lauren Hartley-Tassell, Thomas Ve, Laura M Desrochers, Qi Wang, Bostjan Kobe, Giuseppe Orsomando #, Michael P Coleman #

Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

在患有 ALS 和其他运动神经疾病的患者中,编码具有组成性高活性 NADase 的变体的 SARM1 等位基因的富集

Jonathan Gilley, Oscar Jackson, Menelaos Pipis, Mehrdad A Estiar, Ammar Al-Chalabi, Matt C Danzi, Kristel R van Eijk, Stephen A Goutman, Matthew B Harms, Henry Houlden, Alfredo Iacoangeli, Julia Kaye, Leandro Lima; Queen Square Genomics; John Ravits, Guy A Rouleau, Rebecca Schüle, Jishu Xu, Stephan

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

线粒体损伤通过 NMNAT2 的消耗激活沃勒通路,导致 SARM1 依赖性轴突变性

Andrea Loreto, Ciaran S Hill, Victoria L Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P Coleman