日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

利用人诱导多能干细胞来源的小胶质细胞将疾病修饰蛋白递送至中枢神经系统各处

Jean Paul Chadarevian ,Hayk Davtyan ,Alina L Chadarevian ,Jasmine Nguyen ,Joia K Capocchi ,Lauren Le ,Adrian Escobar ,Talar Chadarevian ,Kimiya Mansour ,Ekaterina Deynega ,Michael Mgerian ,Christina Tu ,Sepideh Kiani Shabestari ,William Carlen-Jones ,Ghazaleh Eskandari-Sedighi ,Jonathan Hasselmann ,Robert C Spitale ,Mathew Blurton-Jones

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo

人小胶质细胞在体内对β-淀粉样蛋白、tau蛋白以及阿尔茨海默病病理的混合反应存在差异。

Morgan A Coburn ,Ghazaleh Eskandari-Sedighi ,Jonathan Hasselmann ,Whitney England ,Sepideh Kiani Shabestari ,Kimiya Mansour ,Amanda McQuade ,Michael Armen Mgerian ,Jean Paul Chadarevian ,Christina Tu ,Jorge Silva ,Jaclyn Beck ,Zahara Keulen ,Robert C Spitale ,Hayk Davtyan ,Mathew Blurton-Jones

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

人类小胶质细胞移植在CSF1R相关脑白质病嵌合模型中的治疗潜力

Jean Paul Chadarevian ,Jonathan Hasselmann ,Alina Lahian ,Joia K Capocchi ,Adrian Escobar ,Tau En Lim ,Lauren Le ,Christina Tu ,Jasmine Nguyen ,Sepideh Kiani Shabestari ,William Carlen-Jones ,Sunil Gandhi ,Guojun Bu ,David A Hume ,Clare Pridans ,Zbigniew K Wszolek ,Robert C Spitale ,Hayk Davtyan ,Mathew Blurton-Jones

Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

设计一种抑制剂抗性的人类 CSF1R 变体用于小胶质细胞替代

Jean Paul Chadarevian #, Sonia I Lombroso #, Graham C Peet, Jonathan Hasselmann, Christina Tu, Dave E Marzan, Joia Capocchi, Freddy S Purnell, Kelsey M Nemec, Alina Lahian, Adrian Escobar, Whitney England, Sai Chaluvadi, Carleigh A O'Brien, Fazeela Yaqoob, William H Aisenberg, Matias Porras-Paniagua

The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model

PLCG2的P522R保护性变体在阿尔茨海默病小鼠模型中促进人小胶质细胞表达抗原呈递基因。

Christel Claes ,Whitney E England ,Emma P Danhash ,Sepideh Kiani Shabestari ,Amit Jairaman ,Jean Paul Chadarevian ,Jonathan Hasselmann ,Andy P Tsai ,Morgan A Coburn ,Jessica Sanchez ,Tau En Lim ,Jorge L S Hidalgo ,Christina Tu ,Michael D Cahalan ,Bruce T Lamb ,Gary E Landreth ,Robert C Spitale ,Mathew Blurton-Jones ,Hayk Davtyan

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

小胶质细胞缺失会导致阿尔茨海默病小鼠出现多种病理变化和早期死亡。

Sepideh Kiani Shabestari ,Samuel Morabito ,Emma Pascal Danhash ,Amanda McQuade ,Jessica Ramirez Sanchez ,Emily Miyoshi ,Jean Paul Chadarevian ,Christel Claes ,Morgan Alexandra Coburn ,Jonathan Hasselmann ,Jorge Hidalgo ,Kayla Nhi Tran ,Alessandra C Martini ,Winston Chang Rothermich ,Jesse Pascual ,Elizabeth Head ,David A Hume ,Clare Pridans ,Hayk Davtyan ,Vivek Swarup ,Mathew Blurton-Jones

Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

针对人类 α-突触核蛋白的 MultiTEP DNA 疫苗的功效和免疫原性:IND 授权研究的前奏

Changyoun Kim #, Armine Hovakimyan #, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G Agadjanyan

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease

斑块相关的人类小胶质细胞在阿尔茨海默病的嵌合模型中积累脂质滴

Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C Spitale, Hayk Davtyan, Mathew Blurton-Jones

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

基因表达和功能缺陷是阿尔茨海默病人类模型中TREM2敲除小胶质细胞反应的根本原因

Amanda McQuade ,You Jung Kang ,Jonathan Hasselmann ,Amit Jairaman ,Alexandra Sotelo ,Morgan Coburn ,Sepideh Kiani Shabestari ,Jean Paul Chadarevian ,Gianna Fote ,Christina H Tu ,Emma Danhash ,Jorge Silva ,Eric Martinez ,Carl Cotman ,G Aleph Prieto ,Leslie M Thompson ,Joan S Steffan ,Ian Smith ,Hayk Davtyan ,Michael Cahalan ,Hansang Cho ,Mathew Blurton-Jones

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

开发嵌合模型来研究和操纵体内人类小胶质细胞

Jonathan Hasselmann, Morgan A Coburn, Whitney England, Dario X Figueroa Velez, Sepideh Kiani Shabestari, Christina H Tu, Amanda McQuade, Mahshad Kolahdouzan, Karla Echeverria, Christel Claes, Taylor Nakayama, Ricardo Azevedo, Nicole G Coufal, Claudia Z Han, Brian J Cummings, Hayk Davtyan, Christophe