Targeting mTORC2-dependent AKT/FOXO1/RNF125 signaling exploits a therapeutic vulnerability in c-MET-activated and β-catenin-mutated hepatocellular carcinoma
靶向 mTORC2 依赖的 AKT/FOXO1/RNF125 信号通路可利用 c-MET 激活和 β-catenin 突变的肝细胞癌的治疗弱点。
期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000001637
Wang, Xue; Zhou, Yi; Zhang, Shu; Farrar, Christine; Xie, Xuemei; Li, Jiaheng; Zhang, Sophia M; Zhang, Zheng; Yonemura, Andrew; Haynes, Jonathan Toshio; Feng, Xuping; Shang, Runze; Xu, Zhong; Wu, Yanhui; Qiao, Yu; Cui, Guofei; Liao, Weiting; Li, Rong; Calvisi, Diego F; Zhang, Shuxing; Xu, Meng; Chen, Xin; Wang, Haichuan
肿瘤
mTOR
MET
肿瘤免疫
信号转导
NF1
FOXO1
ORC2
细胞生物学
AKT
