日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

经过优化设计的HLA/肽特异性CAR-T细胞在根除实体瘤方面优于TCR-T细胞。

Corinne E Decker,Jacqueline Idun,Katja Mohrs,Thomas Craig Meagher,Iryna Petriv,Jonathon Golas,Robert Salzler,Timothy Helms,Dharani Ajithdoss,Suhasini Avvaru,Jiaxi Wu,Tong Zhang,Eric Smith,Gavin Thurston,John C Lin,Jessica R Kirshner,David J DiLillo

A Novel B7-H4xCD3 Bispecific T-cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune Checkpoint Therapies

一种新型B7-H4xCD3双特异性T细胞衔接器(PF-07260437)与乳腺癌标准疗法和免疫检查点疗法具有协同作用

Keith Abayasiriwardana # ,Lei Wu # ,Hanane Laklai # ,Malgorzata Nocula-Lugowska ,Lioudmila Tchistiakova ,Jatin Narula ,Amy Jackson-Fisher ,Jonathon Golas ,My-Hanh Lam ,Veronika Grinstein ,Jung Wook Kang ,Jessica C Kearney ,Christine Hosselet ,Erik Upeslacis ,LuAnna Lemon ,Yun Zhang ,Changhua Ji ,Bernard S Buetow ,Martin B Finkelstein ,Netonia Marshall ,Stephanie Bisulco ,Edward Rosfjord ,Divya Mathur ,Jennifer Athanacio ,Ashley Thomas ,Alexander Trageser ,Diane Fernandez ,Ziyue Karen Jiang ,Sripad Ram ,Edward Cabral ,Lisa Manzuk ,Kevin Maresca ,Anand Giddabasappa ,Clare Lees ,Andrea T Hooper ,Puja Sapra ,Sudhakar Chintharlapalli

Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade

抗额外结构域 B 剪接变体纤连蛋白抗体-药物偶联物与检查点阻断剂联合使用可增强肿瘤消除效果

Andrea T Hooper, Kimberly Marquette, Chao-Pei Betty Chang, Jonathon Golas, Sadhana Jain, My-Hanh Lam, Magali Guffroy, Mauricio Leal, Hadi Falahatpisheh, Divya Mathur, Ting Chen, Kerry Kelleher, Kiran Khandke, Elwira Muszynska, Frank Loganzo, Edward Rosfjord, Judy Lucas, Zhengyan Kan, Chakrapani Subr

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

NOTCH3 靶向抗体药物偶联物通过诱导受体细胞凋亡和通过内吞作用进入配体细胞来消退肿瘤

Kenneth G Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christophe

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture

癌症相关成纤维细胞抑制肺鳞状细胞癌共培养中 SOX2 诱导的发育不良

Shuang Chen, Andreas Giannakou, Sarah Wyman, Janet Gruzas, Jonathon Golas, Wenyan Zhong, Christine Loreth, Latha Sridharan, Ting-Ting Yamin, Marc Damelin, Kenneth G Geles

Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

肿瘤衍生的 EZH2 获得功能突变引起的表观遗传重编程促进了侵袭性的 3D 细胞形态并增强了黑色素瘤肿瘤的生长

Anthony M Barsotti, Michael Ryskin, Wenyan Zhong, Wei-Guo Zhang, Andreas Giannakou, Christine Loreth, Veronica Diesl, Maximillian Follettie, Jonathon Golas, Michelle Lee, Timothy Nichols, Conglin Fan, Gang Li, Stephen Dann, Valeria R Fantin, Kim Arndt, Dominique Verhelle, Robert A Rollins

Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells

针对 5T4(一种在肿瘤起始细胞上表达的癌胚抗原)的抗体-药物偶联物诱导的长期肿瘤消退

Puja Sapra, Marc Damelin, John Dijoseph, Kimberly Marquette, Kenneth G Geles, Jonathon Golas, Maureen Dougher, Bitha Narayanan, Andreas Giannakou, Kiran Khandke, Russell Dushin, Elana Ernstoff, Judy Lucas, Mauricio Leal, George Hu, Christopher J O'Donnell, Lioudmila Tchistiakova, Robert T Abraham, H

Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells

肺癌细胞层次的描绘揭示了肿瘤起始细胞上表达的癌胚抗原

Marc Damelin, Kenneth G Geles, Maximillian T Follettie, Ping Yuan, Michelle Baxter, Jonathon Golas, John F DiJoseph, Maha Karnoub, Shuguang Huang, Veronica Diesl, Carmen Behrens, Sung E Choe, Carol Rios, Janet Gruzas, Latha Sridharan, Maureen Dougher, Arthur Kunz, Philip R Hamann, Deborah Evans, Dou