日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A potent Lassa virus antiviral targets an arenavirus virulence determinant

一种强效的拉沙病毒抗病毒药物靶向沙粒病毒的毒力决定因子。

Madu, Ikenna G; Files, Megan; Gharaibeh, Dima N; Moore, Amy L; Jung, Kie-Hoon; Gowen, Brian B; Dai, Dongcheng; Jones, Kevin F; Tyavanagimatt, Shanthakumar R; Burgeson, James R; Korth, Marcus J; Bedard, Kristin M; Iadonato, Shawn P; Amberg, Sean M

Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers

在人体志愿者中,每日单次口服抗正痘病毒化合物ST-246,连续14天,其安全性和药代动力学研究

Chinsangaram, Jarasvech; Honeychurch, Kady M; Tyavanagimatt, Shanthakumar R; Leeds, Janet M; Bolken, Tove' C; Jones, Kevin F; Jordan, Robert; Marbury, Thomas; Ruckle, Jon; Mee-Lee, Denis; Ross, Eric; Lichtenstein, Israel; Pickens, Margaret; Corrado, Michael; Clarke, Jean M; Frimm, Annie M; Hruby, Dennis E

Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers

在人体志愿者中比较单次口服抗正痘病毒化合物ST-246的多晶型i型胶囊与V型胶囊的药代动力学

Chinsangaram, Jarasvech; Honeychurch, Kady M; Tyavanagimatt, Shanthakumar R; Bolken, Tove' C; Jordan, Robert; Jones, Kevin F; Marbury, Thomas; Lichtenstein, Israel; Pickens, Margaret; Corrado, Michael; Landis, Patrick; Clarke, Jean M; Frimm, Annie M; Hruby, Dennis E

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

比较小鼠、兔和猴静脉输注或口服ST-246®后的安全性和药代动力学

Chen, Yali; Amantana, Adams; Tyavanagimatt, Shanthakumar R; Zima, Daniela; Yan, X Steven; Kasi, Gopi; Weeks, Morgan; Stone, Melialani A; Weimers, William C; Samuel, Peter; Tan, Ying; Jones, Kevin F; Lee, Daniel R; Kickner, Shirley S; Saville, Bradley M; Lauzon, Martin; McIntyre, Alan; Honeychurch, Kady M; Jordan, Robert; Hruby, Dennis E; Leeds, Janet M

Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects

健康成年受试者重复口服抗正痘病毒化合物ST-246后的安全性和药代动力学

Jordan, Robert; Chinsangaram, Jarasvech; Bolken, Tove' C; Tyavanagimatt, Shanthakumar R; Tien, Deborah; Jones, Kevin F; Frimm, Annie; Corrado, Michael L; Pickens, Margaret; Landis, Patrick; Clarke, Jean; Marbury, Thomas C; Hruby, Dennis E

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

新型正痘病毒逸出抑制剂ST-246的单剂量安全性和药代动力学研究

Jordan, Robert; Tien, Deborah; Bolken, Tove' C; Jones, Kevin F; Tyavanagimatt, Shanthakumar R; Strasser, Josef; Frimm, Annie; Corrado, Michael L; Strome, Phoebe G; Hruby, Dennis E

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.

鉴定和表征出血热新世界沙粒病毒的强效小分子抑制剂

Bolken Tove C, Laquerre Sylvie, Zhang Yuanming, Bailey Thomas R, Pevear Daniel C, Kickner Shirley S, Sperzel Lindsey E, Jones Kevin F, Warren Travis K, Amanda Lund S, Kirkwood-Watts Dana L, King David S, Shurtleff Amy C, Guttieri Mary C, Deng Yijun, Bleam Maureen, Hruby Dennis E

Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence

单核细胞增生李斯特菌10403S HtrA是抵抗细胞应激和毒力所必需的

Wilson, Rebecca L; Brown, Lindsay L; Kirkwood-Watts, Dana; Warren, Travis K; Lund, S Amanda; King, David S; Jones, Kevin F; Hruby, Dennis E

Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine

志愿者对拟用于未来作为A组链球菌疫苗的戈登链球菌携带菌株进行鼻内和口服联合接种的临床和微生物学反应

Kotloff, Karen L; Wasserman, Steven S; Jones, Kevin F; Livio, Sofie; Hruby, Dennis E; Franke, Christine A; Fischetti, Vincent A