日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Conformationally Constrained ALK2 Inhibitors

构象受限的ALK2抑制剂的发现

González-Álvarez, Héctor; Ensan, Deeba; Xin, Tao; Wong, Jong Fu; Zepeda-Velázquez, Carlos A; Cros, Julien; Sweeney, Melissa N; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J; Aman, Ahmed; Roberts, Owen; Isaac, Methvin B; Bullock, Alex N; Smil, David; Al-Awar, Rima

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

发现两种针对激活素受体样激酶 1 和 2 的高选择性结构正交化学探针

Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Be

Water can trigger nuclear reaction to produce energy and isotope gases

水可以引发核反应,产生能量和同位素气体。

Huang, Bin-Juine; Pan, Yu-Hsiang; Wu, Po-Hsien; Yeh, Jong-Fu; Tso, Ming-Li; Liu, Ying-Hung; Wu, Litu; Huang, Ching-Kang; Chen, I-Fee; Lin, Che-Hao; Tseng, T R; Kang, Fang-Wei; Tsai, Tan-Feng; Lan, Kuan-Che; Chen, Yi-Tung; Liao, Mou-Yung; Xu, Li; Chen, Sih-Li; Greenyer, Robert William

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

PRMT5 抑制在体外对 H3K27M 改变的弥漫性中线胶质瘤有效,但在体内不能延长生存期

Elizabeth J Brown, Leire Balaguer-Lluna, Adam P Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M Carcaboso, Alex N Bullock, Gillian Farnie

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

突变型ACVR1抑制神经胶质细胞分化,从而驱动儿童胶质瘤的发生

Jerome Fortin ,Ruxiao Tian ,Ida Zarrabi ,Graham Hill ,Eleanor Williams ,Gonzalo Sanchez-Duffhues ,Midory Thorikay ,Parameswaran Ramachandran ,Robert Siddaway ,Jong Fu Wong ,Annette Wu ,Lorraine N Apuzzo ,Jillian Haight ,Annick You-Ten ,Bryan E Snow ,Andrew Wakeham ,David J Goldhamer ,Daniel Schramek ,Alex N Bullock ,Peter Ten Dijke ,Cynthia Hawkins ,Tak W Mak

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

靶向ALK2:采用开放科学方法开发治疗弥漫性内生性脑桥胶质瘤的疗法

Ensan, Deeba; Smil, David; Zepeda-Velázquez, Carlos A; Panagopoulos, Dimitrios; Wong, Jong Fu; Williams, Eleanor P; Adamson, Roslin; Bullock, Alex N; Kiyota, Taira; Aman, Ahmed; Roberts, Owen G; Edwards, Aled M; O'Meara, Jeff A; Isaac, Methvin B; Al-Awar, Rima

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

利用开放科学药物发现模型开发中枢神经系统渗透性 ALK2 抑制剂,用于治疗弥漫性内在性脑桥胶质瘤

David Smil, Jong Fu Wong, Eleanor P Williams, Roslin J Adamson, Alison Howarth, David A McLeod, Ahmed Mamai, Soyoung Kim, Brian J Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J Nicole Hamblin, Sue Cramp, Owen G Roberts, Aled M Edwa

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

针对激活素受体样激酶 ALK4 和 ALK5 的高选择性化学探针

Thomas Hanke, Jong Fu Wong, Benedict-Tilman Berger, Ismahan Abdi, Lena Marie Berger, Roberta Tesch, Claudia Tredup, Alex N Bullock, Susanne Müller, Stefan Knapp

Fostering open collaboration in drug development for paediatric brain tumours

促进儿童脑肿瘤药物研发领域的开放式合作

Wong, Jong Fu; Brown, Elizabeth J; Williams, Eleanor; Bullock, Alex N