日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PI3Kγ inhibition drives M1 macrophage differentiation and synergizes with PD-L1 blockade to improve survival in poorly immunogenic head and neck squamous cell carcinoma

PI3Kγ抑制剂可促进M1型巨噬细胞分化,并与PD-L1阻断剂协同作用,提高免疫原性较差的头颈部鳞状细胞癌患者的生存率。

Jordanides, Pete P; Jagadeesha, Sushmitha; Upadhaya, Puja; Ryan, Nathan M; Anderson, Kelvin; Lamenza, Felipe F; Shrestha, Suvekshya; Siddiqui, Arham; Bopp, Anna R; Pracha, Sherefuddin H; Roth, Peyton; Kehres, Reegan; Mo, Xiaokui; Oghumu, Steve

Inhibition of head and neck squamous cell carcinoma by Bruton's tyrosine kinase inhibitor ibrutinib is associated with reduction of immunosuppressive T cells.

布鲁顿酪氨酸激酶抑制剂伊布替尼对头颈部鳞状细胞癌的抑制作用与免疫抑制性 T 细胞的减少有关

Bopp Anna R, Lamenza Felipe F, Upadhaya Puja, Ryan Nathan M, Kazmierowicz Natalie, Jordanides Pete P, Siddiqui Arham, Pracha Sherefuddin H, Roth Peyton, Iwenofu O Hans, Oghumu Steve

Targeting macrophage migration inhibitory factor to inhibit T cell immunosuppression in the tumor microenvironment and improve cancer outcomes in head and neck squamous cell carcinoma.

靶向巨噬细胞迁移抑制因子,抑制肿瘤微环境中的T细胞免疫抑制,改善头颈部鳞状细胞癌的治疗效果

Pracha S Hasan, Shrestha Suvekshya, Ryan Nathan, Upadhaya Puja, Lamenza Felipe F, Jagadeesha Sushmitha, Jordanides Pete, Roth Peyton, Springer Anna, Oghumu Steve

Host derived macrophage migration inhibitory factor expression attenuates anti-tumoral immune cell accumulation and promotes immunosuppression in the tumor microenvironment of head and neck squamous cell carcinoma.

宿主来源的巨噬细胞迁移抑制因子表达减弱了抗肿瘤免疫细胞的积累,并促进了头颈部鳞状细胞癌肿瘤微环境中的免疫抑制

Ryan Nathan, Lamenza Felipe, Shrestha Suvekshya, Upadhaya Puja, Springer Anna, Jordanides Pete, Pracha Hasan, Roth Peyton, Kumar Rathan, Wang Yinchong, Vilgelm Anna E, Satoskar Abhay, Oghumu Steve

Ionizing Radiation Reduces Head and Neck Squamous Cell Carcinoma Cell Viability and Is Associated with Predictive Tumor-Specific T Cell Responses

电离辐射降低头颈部鳞状细胞癌细胞的活力,并与预测性肿瘤特异性T细胞反应相关

Upadhaya, Puja; Ryan, Nathan; Roth, Peyton; Pero, Travis; Lamenza, Felipe; Springer, Anna; Jordanides, Pete; Pracha, Hasan; Mitchell, Darrion; Oghumu, Steve