日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of mCMV280: An Oral Ectoparasiticide in the Isoxazoline Class with Reduced Mammalian Brain Exposure

mCMV280 的发现:一种异噁唑啉类口服体外寄生虫杀灭剂,可降低哺乳动物大脑暴露量

McComic, Sarah E; Wilson, Katy B; Li, Zhilin; Chen, Jeffrey; Weiss, Frank; Song, Lirui; Mazumdar, Wrickban; Dvorak, Curt A; Brittain, Jason; Lee, Kyoung-Jin; Li, Shuangwei; Joseph, Sean B; McNamara, Case W; Vos, Martijn W; Sheshachalam, Avinash; Inácio, Alex; Dechering, Koen J; Chatterjee, Arnab K; Swale, Daniel R

SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于 SuFEx 的抗结核化合物不可逆地抑制 Pks13

Krieger, Inna V; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A L; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L; Massoudi, Lisa M; Woolhiser, Lisa K; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R; Kandula, Dilipkumar Reddy; McCabe, Jacob W; Guo, Taijie; Alland, David; Boshoff, Helena I; Schnappinger, Dirk; Robertson, Gregory T; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G; Joseph, Sean B; Love, Melissa S; Sharpless, K Barry; Petrassi, H Michael; Chatterjee, Arnab K; Sacchettini, James C; McNamara, Case W

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.

药物再利用方法揭示了间日疟原虫休眠子中可靶向的表观遗传通路

Maher Steven P, Bakowski Malina A, Vantaux Amélie, Flannery Erika L, Andolina Chiara, Gupta Mohit, Antonova-Koch Yevgeniya, Argomaniz Magdalena, Cabrera-Mora Monica, Campo Brice, Chao Alexander T, Chatterjee Arnab K, Cheng Wayne T, Chuenchob Vorada, Cooper Caitlin A, Cottier Karissa, Galinski Mary R, Harupa-Chung Anke, Ji Hana, Joseph Sean B, Lenz Todd, Lonardi Stefano, Matheson Jessica, Mikolajczak Sebastian A, Moeller Timothy, Orban Agnes, Padín-Irizarry Vivian, Pan Kastin, Péneau Julie, Prudhomme Jacques, Roesch Camille, Ruberto Anthony, Sabnis Saniya S, Saney Celia L, Sattabongkot Jetsumon, Sereshki Saleh, Suriyakan Sangrawee, Ubalee Ratawan, Wang Yinsheng, Wasisakun Praphan, Yin Jiekai, Popovici Jean, McNamara Case W, Joyner Chester, Nosten François H, Witkowski Benoît, Le Roch Karine G, Kyle Dennis E

NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

NK2R信号通路调控肠道脂质动员和黏膜炎症。

Perez, Pedro A; Liu, Chung-Chih; Ferrari, Alessandra; Littlejohn, Nicole; Kennelly, John Paul; Robinson, Emma; Nguyen-Tran, Vân T B; Athanacio, Jon; Joseph, Sean B; Amso, Zaid; Tontonoz, Peter; Srinivasan, Supriya

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead

CMX990 的发现:一种带有新型弹头的强效 SARS-CoV-2 3CL 蛋白酶抑制剂

Dayan Elshan, N G R; Wolff, Karen C; Riva, Laura; Woods, Ashley K; Grabovyi, Gennadii; Wilson, Katy; Pedroarena, James; Ghorai, Sourav; Nazarian, Armen; Weiss, Frank; Liu, Yuyin; Mazumdar, Wrickban; Song, Lirui; Okwor, Neechi; Malvin, Jacqueline; Bakowski, Malina A; Beutler, Nathan; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; Huang, Edward; Nguyen-Tran, Vân T B; Chi, Victor; Li, Shuangwei; Rogers, Thomas F; McNamara, Case W; Gupta, Anil Kumar; Rahimi, Alireza; Chen, Jian Jeffrey; Joseph, Sean B; Schultz, Peter G; Chatterjee, Arnab K

Correction to "Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead"

对“CMX990的发现:一种带有新型弹头的强效SARS-CoV-2 3CL蛋白酶抑制剂”一文的更正

Elshan, N G R Dayan; Wolff, Karen C; Riva, Laura; Woods, Ashley K; Grabovyi, Gennadii; Wilson, Katy; Pedroarena, James; Ghorai, Sourav; Nazarian, Armen; Weiss, Frank; Liu, Yuyin; Mazumdar, Wrickban; Song, Lirui; Okwor, Neechi; Malvin, Jacqueline; Liu, Dongdong; Bakowski, Malina A; Beutler, Nathan; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; Huang, Edward; Nguyen-Tran, Vân T B; Chi, Victor; Li, Shuangwei; Rogers, Thomas F; McNamara, Case W; Gupta, Anil Kumar; Rahimi, Alireza; Chen, Jian Jeffrey; Joseph, Sean B; Schultz, Peter G; Chatterjee, Arnab K

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

ReFRAME 库作为一个综合性药物重定位库及其在隐孢子虫病治疗中的应用

Janes, Jeff; Young, Megan E; Chen, Emily; Rogers, Nicole H; Burgstaller-Muehlbacher, Sebastian; Hughes, Laura D; Love, Melissa S; Hull, Mitchell V; Kuhen, Kelli L; Woods, Ashley K; Joseph, Sean B; Petrassi, H Michael; McNamara, Case W; Tremblay, Matthew S; Su, Andrew I; Schultz, Peter G; Chatterjee, Arnab K

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

LXR信号传导将甾醇代谢与获得性免疫反应中的细胞增殖联系起来

Bensinger, Steven J; Bradley, Michelle N; Joseph, Sean B; Zelcer, Noam; Janssen, Edith M; Hausner, Mary Ann; Shih, Roger; Parks, John S; Edwards, Peter A; Jamieson, Beth D; Tontonoz, Peter

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

配体激活LXRβ可逆转缺乏LXRα和apoE的小鼠的动脉粥样硬化和细胞胆固醇过载。

Bradley, Michelle N; Hong, Cynthia; Chen, Mingyi; Joseph, Sean B; Wilpitz, Damien C; Wang, Xuping; Lusis, Aldons J; Collins, Allan; Hseuh, Willa A; Collins, Jon L; Tangirala, Rajendra K; Tontonoz, Peter

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

巨噬细胞肝X受体作为动脉粥样硬化抑制剂的鉴定

Tangirala, Rajendra K; Bischoff, Eric D; Joseph, Sean B; Wagner, Brandee L; Walczak, Robert; Laffitte, Bryan A; Daige, Chris L; Thomas, Diane; Heyman, Richard A; Mangelsdorf, David J; Wang, Xuping; Lusis, Aldons J; Tontonoz, Peter; Schulman, Ira G