Joseph DeSimone相关文献与解析，生知库 | 链接生命科学的每一步

C Tilden Hagan 4th, Cameron Bloomquist, Samuel Warner, Nicole M Knape, Isaiah Kim, Hayley Foley, Kyle T Wagner, Sue Mecham, Joseph DeSimone, Andrew Z Wang

肿瘤

发表日期：2022

文献求助收藏

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study

口服四氢尿苷和地西他滨用于镰状细胞病非细胞毒性表观遗传基因调控：一项随机1期研究

期刊:PLoS Medicine

影响因子:10.5

doi:10.1371/journal.pmed.1002382

Robert Molokie ，Donald Lavelle ，Michel Gowhari ，Michael Pacini ，Lani Krauz ，Johara Hassan ，Vinzon Ibanez ，Maria A Ruiz ，Kwok Peng Ng ，Philip Woost ，Tomas Radivoyevitch ，Daisy Pacelli ，Sherry Fada ，Matthew Rump ，Matthew Hsieh ，John F Tisdale ，James Jacobberger ，Mitch Phelps ，James Douglas Engel ，Santhosh Saraf ，Lewis L Hsu ，Victor Gordeuk ，Joseph DeSimone ，Yogen Saunthararajah

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

药理学抑制 LSD1 和 mTOR 可降低镰状细胞病红细胞中的线粒体滞留和相关 ROS 水平

期刊:Experimental Hematology

影响因子:2.5

doi:10.1016/j.exphem.2017.02.003

Ramasamy Jagadeeswaran, Benjamin A Vazquez, Muthusamy Thiruppathi, Balaji B Ganesh, Vinzon Ibanez, Shuaiying Cui, James D Engel, Alan M Diamond, Robert E Molokie, Joseph DeSimone, Donald Lavelle, Angela Rivers

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

LSD1 抑制剂 RN-1 重现了狒狒（P. anubis）胎儿时期的血红蛋白合成模式

期刊:Haematologica

影响因子:8.2

doi:10.3324/haematol.2015.140749

Angela Rivers, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramasamy Jagadeeswaran, Yogen Saunthararajah, Shuaiying Cui, James D Engel, Joseph DeSimone, Donald Lavelle

信号转导

发表日期：2016

文献求助收藏

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation

红系分化过程中羟甲基胞嘧啶和γ-珠蛋白基因启动子的去甲基化

期刊:Epigenetics

影响因子:2.9

doi:10.1080/15592294.2015.1039220

Maria Armila Ruiz ，Angela Rivers, Vinzon Ibanez, Kestis Vaitkus, Nadim Mahmud, Joseph DeSimone, Donald Lavelle

表观遗传

发表日期：2015

文献求助收藏

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model

RN-1 是一种强效且选择性的赖氨酸特异性脱甲基酶 1 抑制剂，可增加镰状细胞病小鼠模型中的 γ-珠蛋白表达、F 网织红细胞和 F 细胞

期刊:Experimental Hematology

影响因子:2.5

doi:10.1016/j.exphem.2015.04.005

Angela Rivers, Kestis Vaitkus, Maria Armila Ruiz, Vinzon Ibanez, Ramasamy Jagadeeswaran, Tatiana Kouznetsova, Joseph DeSimone, Donald Lavelle

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

四氢尿苷对口服地西他滨药代动力学和药效学的影响

期刊:Blood

影响因子:21

doi:10.1182/blood-2011-08-371690

Donald Lavelle, Kestis Vaitkus, Yonghua Ling, Maria A Ruiz, Reda Mahfouz, Kwok Peng Ng, Soledad Negrotto, Nicola Smith, Pramod Terse, Kory J Engelke, Joseph Covey, Kenneth K Chan, Joseph Desimone, Yogen Saunthararajah

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms

用地西他滨治疗的狒狒和培养的红系祖细胞中 γ 珠蛋白基因的转录激活涉及不同的机制

期刊:Experimental Hematology

影响因子:2.5

doi:10.1016/j.exphem.2009.06.007

Janet Chin, Mahipal Singh, Virryan Banzon, Kestis Vaitkus, Vinzon Ibanez, Tatiana Kouznetsova, Nadim Mahmud, Joseph DeSimone, Donald Lavelle

3D printed drug-loaded implantable devices for intraoperative treatment of cancer

3D 打印载药植入装置用于癌症术中治疗

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study

口服四氢尿苷和地西他滨用于镰状细胞病非细胞毒性表观遗传基因调控：一项随机1期研究

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

药理学抑制 LSD1 和 mTOR 可降低镰状细胞病红细胞中的线粒体滞留和相关 ROS 水平

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

LSD1 抑制剂 RN-1 重现了狒狒（P. anubis）胎儿时期的血红蛋白合成模式

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation

红系分化过程中羟甲基胞嘧啶和γ-珠蛋白基因启动子的去甲基化

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model

RN-1 是一种强效且选择性的赖氨酸特异性脱甲基酶 1 抑制剂，可增加镰状细胞病小鼠模型中的 γ-珠蛋白表达、F 网织红细胞和 F 细胞

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

四氢尿苷对口服地西他滨药代动力学和药效学的影响

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms

用地西他滨治疗的狒狒和培养的红系祖细胞中 γ 珠蛋白基因的转录激活涉及不同的机制