日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly Multiplexed Spatially Resolved Proteomic and Transcriptional Profiling of the Glioblastoma Microenvironment Using Archived Formalin-Fixed Paraffin-Embedded Specimens

使用存档的福尔马林固定石蜡包埋样本对胶质母细胞瘤微环境进行高度多路复用空间分辨蛋白质组学和转录分析

Youngmi Kim, Patrick Danaher, Patrick J Cimino, Kyle Hurth, Sarah Warren, John Glod, Joseph M Beechem, Gabriel Zada, Troy A McEachron

Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma

黑色素瘤肿瘤内 PTEN 异质性的多平台分析

Sharmeen Chagani, Mariana P De Macedo, Fernando Carapeto, Feng Wang, Diego M Marzese, Khalida Wani, Lauren E Haydu, Weiyi Peng, Giang T Ong, Sarah E Warren, Joseph M Beechem, Dave S B Hoon, Gordon B Mills, Michael T Tetzlaff, Alexander J Lazar, Lawrence N Kwong, Michael A Davies

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

胰腺癌的单细胞核和空间转录组分析揭示了与新辅助治疗相关的多细胞动态变化

William L Hwang # ,Karthik A Jagadeesh # ,Jimmy A Guo # ,Hannah I Hoffman # ,Payman Yadollahpour ,Jason W Reeves ,Rahul Mohan ,Eugene Drokhlyansky ,Nicholas Van Wittenberghe ,Orr Ashenberg ,Samouil L Farhi ,Denis Schapiro ,Prajan Divakar ,Eric Miller ,Daniel R Zollinger ,George Eng ,Jason M Schenkel ,Jennifer Su ,Carina Shiau ,Patrick Yu ,William A Freed-Pastor ,Domenic Abbondanza ,Arnav Mehta ,Joshua Gould ,Conner Lambden ,Caroline B M Porter ,Alexander Tsankov ,Danielle Dionne ,Julia Waldman ,Michael S Cuoco ,Lan Nguyen ,Toni Delorey ,Devan Phillips ,Jaimie L Barth ,Marina Kem ,Clifton Rodrigues ,Debora Ciprani ,Jorge Roldan ,Piotr Zelga ,Vjola Jorgji ,Jonathan H Chen ,Zackery Ely ,Daniel Zhao ,Kit Fuhrman ,Robin Fropf ,Joseph M Beechem ,Jay S Loeffler ,David P Ryan ,Colin D Weekes ,Cristina R Ferrone ,Motaz Qadan ,Martin J Aryee ,Rakesh K Jain ,Donna S Neuberg ,Jennifer Y Wo ,Theodore S Hong ,Ramnik Xavier ,Andrew J Aguirre ,Orit Rozenblatt-Rosen ,Mari Mino-Kenudson ,Carlos Fernandez-Del Castillo ,Andrew S Liss ,David T Ting ,Tyler Jacks ,Aviv Regev

Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data

混合细胞反卷积的进展使得空间转录组数据中的细胞类型量化成为可能

Patrick Danaher #, Youngmi Kim #, Brenn Nelson, Maddy Griswold, Zhi Yang, Erin Piazza, Joseph M Beechem

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

免疫和遗传机制的拮抗作用塑造了滑膜肉瘤的致癌程序

Livnat Jerby-Arnon # ,Cyril Neftel # ,Marni E Shore ,Hannah R Weisman ,Nathan D Mathewson ,Matthew J McBride ,Brian Haas ,Benjamin Izar ,Angela Volorio ,Gaylor Boulay ,Luisa Cironi ,Alyssa R Richman ,Liliane C Broye ,Joseph M Gurski ,Christina C Luo ,Ravindra Mylvaganam ,Lan Nguyen ,Shaolin Mei ,Johannes C Melms ,Christophe Georgescu ,Ofir Cohen ,Jorge E Buendia-Buendia ,Asa Segerstolpe ,Malika Sud ,Michael S Cuoco ,Danny Labes ,Simon Gritsch ,Daniel R Zollinger ,Nicole Ortogero ,Joseph M Beechem ,G Petur Nielsen ,Ivan Chebib ,Tu Nguyen-Ngoc ,Michael Montemurro ,Gregory M Cote ,Edwin Choy ,Igor Letovanec ,Stéphane Cherix ,Nikhil Wagle ,Peter K Sorger ,Alex B Haynes ,John T Mullen ,Ivan Stamenkovic ,Miguel N Rivera ,Cigall Kadoch ,Kai W Wucherpfennig ,Orit Rozenblatt-Rosen ,Mario L Suvà ,Nicolò Riggi ,Aviv Regev

High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling: A Technology Designed for Immuno-oncology Biomarker Discovery and Translational Research

利用数字空间分析进行高复杂度空间分辨 RNA 和蛋白质检测:专为免疫肿瘤生物标志物发现和转化研究而设计的技术

Joseph M Beechem

GeoMx™ RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue

GeoMx™ RNA 检测:FFPE 组织中 RNA 的高倍数、数字化、空间分析

Daniel R Zollinger, Stan E Lingle, Kristina Sorg, Joseph M Beechem, Christopher R Merritt

A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis

致命性检查点抑制剂诱发的脑炎中出现克隆性 EBV 样记忆 CD4+ T 细胞活化的病例报告

Douglas B Johnson #, Wyatt J McDonnell #, Paula I Gonzalez-Ericsson, Rami N Al-Rohil, Bret C Mobley, Joe-Elie Salem, Daniel Y Wang, Violeta Sanchez, Yu Wang, Cody A Chastain, Kristi Barker, Yan Liang, Sarah Warren, Joseph M Beechem, Alexander M Menzies, Martin Tio, Georgina V Long, Justine V Cohen, 

High-Plex Predictive Marker Discovery for Melanoma Immunotherapy-Treated Patients Using Digital Spatial Profiling

利用数字空间分析为接受黑色素瘤免疫疗法治疗的患者发现高复合预测标记物

Maria I Toki, Christopher R Merritt, Pok Fai Wong, James W Smithy, Harriet M Kluger, Konstantinos N Syrigos, Giang T Ong, Sarah E Warren, Joseph M Beechem, David L Rimm

Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies

使用 DNA 条形码抗体评估蛋白质裂解物的多重定量蛋白质组学平台的实现

Jinho Lee, Gary K Geiss, Gokhan Demirkan, Christopher P Vellano, Brian Filanoski, Yiling Lu, Zhenlin Ju, Shuangxing Yu, Huifang Guo, Lisa Y Bogatzki, Warren Carter, Rhonda K Meredith, Savitri Krishnamurthy, Zhiyong Ding, Joseph M Beechem, Gordon B Mills