日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

PARP7 负向调节癌细胞中的 I 型干扰素反应,其抑制可触发抗肿瘤免疫

Joseph M Gozgit, Melissa M Vasbinder, Ryan P Abo, Kaiko Kunii, Kristy G Kuplast-Barr, Bin Gui, Alvin Z Lu, Jennifer R Molina, Elena Minissale, Kerren K Swinger, Tim J Wigle, Danielle J Blackwell, Christina R Majer, Yue Ren, Mario Niepel, Zacharenia A Varsamis, Sunaina P Nayak, Ellen Bamberg, Jan-Run

RET fusions observed in lung and colorectal cancers are sensitive to ponatinib

在肺癌和结直肠癌中观察到的 RET 融合对普纳替尼敏感

Joseph M Gozgit, Tzu-Hsiu Chen, Youngchul Song, Scott Wardwell, Frank Wang, Jie Cai, Henry Li, Henrik Edgren, Victor M Rivera, Justin Pritchard

Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients

帕奈替尼可抑制多克隆耐药性 KIT 癌蛋白,并对接受过大量治疗的胃肠道间质瘤 (GIST) 患者显示出治疗潜力

Andrew P Garner #, Joseph M Gozgit #, Rana Anjum, Sadanand Vodala, Alexa Schrock, Tianjun Zhou, Cesar Serrano, Grant Eilers, Meijun Zhu, Julia Ketzer, Scott Wardwell, Yaoyu Ning, Youngchul Song, Anna Kohlmann, Frank Wang, Tim Clackson, Michael C Heinrich, Jonathan A Fletcher, Sebastian Bauer, Victor

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

普纳替尼 (AP24534) 在 FLT3 驱动的急性髓系白血病和其他血液系统恶性肿瘤模型中具有强效活性

Joseph M Gozgit, Matthew J Wong, Scott Wardwell, Jeffrey W Tyner, Marc M Loriaux, Qurish K Mohemmad, Narayana I Narasimhan, William C Shakespeare, Frank Wang, Brian J Druker, Tim Clackson, Victor M Rivera

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

JAK2 抑制剂 AZD1480 可有效阻断实体肿瘤中的 Stat3 信号传导和癌变

Michael Hedvat, Dennis Huszar, Andreas Herrmann, Joseph M Gozgit, Anne Schroeder, Adam Sheehy, Ralf Buettner, David Proia, Claudia M Kowolik, Hong Xin, Brian Armstrong, Geraldine Bebernitz, Shaobu Weng, Lin Wang, Minwei Ye, Kristen McEachern, Huawei Chen, Deborah Morosini, Kirsten Bell, Marat Alimzh