日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

利用设计的寡聚体组装体调控FGF通路信号传导和血管分化

Natasha I Edman ,Ashish Phal ,Rachel L Redler ,Thomas Schlichthaerle ,Sanjay R Srivatsan ,Devon Duron Ehnes ,Ali Etemadi ,Seong J An ,Andrew Favor ,Zhe Li ,Florian Praetorius ,Max Gordon ,Thomas Vincent ,Silvia Marchiano ,Leslie Blakely ,Chuwei Lin ,Wei Yang ,Brian Coventry ,Derrick R Hicks ,Longxing Cao ,Neville Bethel ,Piper Heine ,Analisa Murray ,Stacey Gerben ,Lauren Carter ,Marcos Miranda ,Babak Negahdari ,Sangwon Lee ,Cole Trapnell ,Ying Zheng ,Charles E Murry ,Devin K Schweppe ,Benjamin S Freedman ,Lance Stewart ,Damian C Ekiert ,Joseph Schlessinger ,Jay Shendure ,Gira Bhabha ,Hannele Ruohola-Baker ,David Baker

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

KIT 和致癌突变体的低温电子显微镜分析揭示了结构致癌可塑性和治疗干预的目标

Stefan G Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

肝素对于 FGF21 的最佳细胞信号传导和 βKlotho 细胞稳定性的调节至关重要

Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

通过从头设计的微型蛋白实现对FGFR信号传导的亚型特异性抑制

Joon Sung Park ,Jungyuen Choi ,Longxing Cao ,Jyotidarsini Mohanty ,Yoshihisa Suzuki ,Andy Park ,David Baker ,Joseph Schlessinger ,Sangwon Lee

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

关于强效、选择性和细胞通透性伪激酶结构域配体对 JAK2 调节的见解

Maria-Elena Liosi, Joseph A Ippolito, Sean P Henry, Stefan G Krimmer, Ana S Newton, Kara J Cutrona, Rene A Olivarez, Jyotidarsini Mohanty, Joseph Schlessinger, William L Jorgensen

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

胞吐介导的胞吐作用对 EGF 刺激的 PI-3K/AKT 通路激活的调节

Seong J An, Alexander Anneken, Zhiqun Xi, Changseon Choi, Joseph Schlessinger, Derek Toomre

Mechanism for the activation of the anaplastic lymphoma kinase receptor

间变性淋巴瘤激酶受体的激活机制

Andrey V Reshetnyak #, Paolo Rossi #, Alexander G Myasnikov #, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J Miller, Irit Lax, Joseph Schlessinger, Charalampos G Kalodimos

Structural basis for ligand reception by anaplastic lymphoma kinase

间变性淋巴瘤激酶接受配体的结构基础

Tongqing Li, Steven E Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X Walker, Krishna C Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A Lemmon, Joseph Schlessinger, Daryl E Klein

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

具有二氨基三唑核心的选择性 Janus 激酶 2 (JAK2) 假激酶配体

Maria-Elena Liosi, Stefan G Krimmer, Ana S Newton, Thomas K Dawson, David E Puleo, Kara J Cutrona, Yoshihisa Suzuki, Joseph Schlessinger, William L Jorgensen

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

β-klotho 的结构揭示了内分泌 FGF 信号传导的“邮政编码”类机制

Sangwon Lee, Jungyuen Choi, Jyotidarsini Mohanty, Leiliane P Sousa, Francisco Tome, Els Pardon, Jan Steyaert, Mark A Lemmon, Irit Lax, Joseph Schlessinger