日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia

Venetoclax联合gilteritinib在FLT3突变型BCL11B-a谱系不明确白血病的临床前模型中有效。

Lindsey E Montefiori,Ilaria Iacobucci,Qingsong Gao,Jamila Moore,William C Wright,Huimei Wei,Pradyumna Baviskar,Surbhi Sona,Hongjian Jin,Amit Budhraja,Josi Lott,Qi Zhang Tatarata,Zhongshan Cheng,Tanya Khan,Emily A Backhaus Wagner,Melissa Johnson,Cyrus M Mehr,Burgess Freeman,Laura Janke,Torsten Haferlach,Paul Geeleher,Paul E Mead,Marina Konopleva,Joseph T Opferman,Charles G Mullighan

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

DNTT介导的DNA损伤反应驱动B细胞急性淋巴细胞白血病对inotuzumab ozogamicin产生耐药性

Carolin S Escherich ,Takaya Moriyama ,Zhenhua Li ,Yu-Chih Hsiao ,Wenjian Yang ,Yizhen Li ,Noemi Reyes ,Megan Walker ,Amit Budhraja ,Sheetal Bhatara ,Ernesto Diaz-Flores ,Wendy Stock ,Elisabeth Paietta ,Marina Y Konopleva ,Steven M Kornblau ,Mark R Litzow ,Hiroto Inaba ,Ching-Hon Pui ,Joseph T Opferman ,Mignon L Loh ,Jiyang Yu ,Maureen M O'Brien ,William E Evans ,Jun J Yang

Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

抗凋亡蛋白MCL-1通过与ACSL1相互作用促进长链脂肪酸氧化

Tristen Wright ,Meghan E Turnis ,Christy R Grace ,Xiao Li ,Lauren A Brakefield ,Yong-Dong Wang ,Haiyan Xu ,Ewa Kaminska ,Leslie K Climer ,Tresor O Mukiza ,Chi-Lun Chang ,Tudor Moldoveanu ,Joseph T Opferman

Genetic ablation of Immt induces a lethal disruption of the MICOS complex

Immt 基因消融可导致 MICOS 复合物的致命破坏

Stephanie M Rockfield, Meghan E Turnis, Ricardo Rodriguez-Enriquez, Madhavi Bathina, Seng Kah Ng, Nathan Kurtz, Nathalie Becerra Mora, Stephane Pelletier, Camenzind G Robinson, Peter Vogel, Joseph T Opferman

Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

靶向MCL-1可引发DNA损伤和抗增殖反应,且该反应独立于细胞凋亡诱导。

Utsarga Adhikary ,Joao A Paulo ,Marina Godes ,Shrabasti Roychoudhury ,Michelle S Prew ,Yael Ben-Nun ,Ellen W Yu ,Amit Budhraja ,Joseph T Opferman ,Dipanjan Chowdhury ,Steven P Gygi ,Loren D Walensky

Combination of MCL-1 and BCL-2 inhibitors is a promising approach for a host-directed therapy for tuberculosis

MCL-1 和 BCL-2 抑制剂的联合应用是一种很有前景的针对结核病的宿主导向疗法。

Eusondia Arnett ,Susanta Pahari ,Chrissy M Leopold Wager ,Elizabeth Hernandez ,Jordan R Bonifacio ,Miranda Lumbreras ,Charles Renshaw ,Maria J Montoya ,Joseph T Opferman ,Larry S Schlesinger

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

MCL-1是癌症对脂肪酸氧化依赖性的关键调控因子。

Michelle S Prew ,Utsarga Adhikary ,Dong Wook Choi ,Erika P Portero ,Joao A Paulo ,Pruthvi Gowda ,Amit Budhraja ,Joseph T Opferman ,Steven P Gygi ,Nika N Danial ,Loren D Walensky

Requirement for antiapoptotic MCL-1 during early erythropoiesis

早期红细胞生成过程中需要抗凋亡 MCL-1

Meghan E Turnis, Ewa Kaminska, Kaitlyn H Smith, Brittany J Kartchner, Peter Vogel, Jonathan D Laxton, Richard A Ashmun, Paul A Ney, Joseph T Opferman

The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis

Mcl-1在胚胎神经前体细胞凋亡中的作用

Robert T Flemmer ,Sarah P Connolly ,Brittany A Geizer ,Joseph T Opferman ,Jacqueline L Vanderluit

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

血红素调节抑制剂通路调节预后不良的 B 系急性白血病对 BH3 类似物的敏感性

Kaitlyn H Smith #, Amit Budhraja #, John Lynch, Kathryn Roberts, John C Panetta, Jon P Connelly, Meghan E Turnis, Shondra M Pruett-Miller, John D Schuetz, Charles G Mullighan, Joseph T Opferman