日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G

JNJ-78306358 是一种首创的双特异性 T 细胞接合抗体,靶向 CD3 和 HLA-G。

Nataša Obermajer ,Adam Zwolak ,Kelly van de Ven ,Shana Versmissen ,Krista Menard ,Katharine Rogers ,Ted Petley ,Dan Weinstock ,Jason Aligo ,Jaymala Patel ,Ken Tian ,Lorraine Angelillo ,Fang Yi ,Stephen Jarantow ,Keith Schutsky ,Yoshitomo Hamuro ,Diana Alvarez Arias ,Kristel Buyens ,Tsun-Wen Sheena Yao ,Vince Torti ,Aleksandra Brajic ,Brian Geist ,Marjolein van Heerden ,Gerald Chu ,Bie Verbist ,Maté Ongenaert ,Julien Häsler ,Kathryn Packman ,Jacintha Shenton ,Laurie Lenox ,Jacalyn Clawson ,Regina J Brown ,Josh Lauring ,James G Greger ,Dirk Brehmer ,Sanjaya Singh ,Matthew V Lorenzi ,Sylvie Laquerre

Safety and clinical activity of JNJ-78306358, a human leukocyte antigen-G (HLA-G) x CD3 bispecific antibody, for the treatment of advanced stage solid tumors

人类白细胞抗原-G (HLA-G) x CD3 双特异性抗体 JNJ-78306358 用于治疗晚期实体肿瘤的安全性和临床活性

Ravit Geva, Maria Vieito, Jorge Ramon, Ruth Perets, Manuel Pedregal, Elena Corral, Bernard Doger, Emiliano Calvo, Jorge Bardina, Elena Garralda, Regina J Brown, James G Greger, Shujian Wu, Douglas Steinbach, Tsun-Wen Sheena Yao, Yu Cao, Josh Lauring, Ruchi Chaudhary, Jaymala Patel, Bharvin Patel, Vi

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

活跃的生长信号促进衰老和癌细胞对 CDK7 抑制的敏感性

Gemma A Wilson, Karla Vuina, Georgina Sava, Caroline Huard, Leticia Meneguello, Jasmin Coulombe-Huntington, Thierry Bertomeu, Rory J Maizels, Josh Lauring, Janos Kriston-Vizi, Mike Tyers, Simak Ali, Cosetta Bertoli, Robertus A M de Bruin

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

PIK3CA 突变和 TP53 变异共同增加癌症表型和肿瘤异质性

Sarah Croessmann, Hong Yuen Wong, Daniel J Zabransky, David Chu, D Marc Rosen, Justin Cidado, Rory L Cochran, W Brian Dalton, Bracha Erlanger, Karen Cravero, Berry Button, Kelly Kyker-Snowman, Paula J Hurley, Josh Lauring, Ben Ho Park

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

磷酸肌醇 3-激酶通过动员肌动蛋白细胞骨架中的醛缩酶来调节糖酵解

Hai Hu, Ashish Juvekar, Costas A Lyssiotis, Evan C Lien, John G Albeck, Doogie Oh, Gopal Varma, Yin Pun Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark R Lundquist, Dean R Tolan, Aaron K Grant, Daniel J Needleman, John M Asara, Lewis C Cantley, Gerburg M Wulf

Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

人类癌症中复发的 AKT 突变:功能后果和对药物敏感性的影响

Kyung H Yi, Josh Lauring

Engineering targeted chromosomal amplifications in human breast epithelial cells

人类乳腺上皮细胞中的靶向染色体扩增工程

Simeon Springer, Kyung H Yi, Jeenah Park, Anandita Rajpurohit, Amanda J Price, Josh Lauring

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

BRCA1 等位基因的功能同源建模揭示了不同的携带者表型

Rory L Cochran, Justin Cidado, Minsoo Kim, Daniel J Zabransky, Sarah Croessmann, David Chu, Hong Yuen Wong, Julia A Beaver, Karen Cravero, Bracha Erlanger, Heather Parsons, Christopher M Heaphy, Alan K Meeker, Josh Lauring, Ben Ho Park

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

TMSB4Y 是 Y 染色体上的候选肿瘤抑制因子,在男性乳腺癌中被删除

Hong Yuen Wong, Grace M Wang, Sarah Croessmann, Daniel J Zabransky, David Chu, Joseph P Garay, Justin Cidado, Rory L Cochran, Julia A Beaver, Anita Aggarwal, Min-Ling Liu, Pedram Argani, Alan Meeker, Paula J Hurley, Josh Lauring, Ben Ho Park

PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system

PIK3CA 和 AKT1 突变对同源管腔乳腺癌模型系统中靶向通路抑制剂的敏感性有不同影响

Julia A Beaver, John P Gustin, Kyung H Yi, Anandita Rajpurohit, Matthew Thomas, Samuel F Gilbert, D Marc Rosen, Ben Ho Park, Josh Lauring