日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques

用靶向生殖系的SOSIP三聚体进行免疫接种,可在幼年猕猴体内诱导产生广谱中和抗体前体。

Ashley N Nelson ,Xiaoying Shen ,Sravani Vekatayogi ,Shiyu Zhang ,Gabriel Ozorowski ,Maria Dennis ,Leigh M Sewall ,Emma Milligan ,Dominique Davis ,Kaitlyn A Cross ,Yue Chen ,Jelle van Schooten ,Joshua Eudailey ,John Isaac ,Saad Memon ,Carolyn Weinbaum ,Hongmei Gao ,Sherry Stanfield-Oakley ,Alliyah Byrd ,Suni Chutkan ,Stella Berendam ,Kenneth Cronin ,Anila Yasmeen ,S Alam ,Celia C LaBranche ,Kenneth Rogers ,Lisa Shirreff ,Albert Cupo ,Ronald Derking ,Francois Villinger ,Per Johan Klasse ,Guido Ferrari ,Wilton B Williams ,Michael G Hudgens ,Andrew B Ward ,David C Montefiori ,Koen K A Van Rompay ,Kevin Wiehe ,John P Moore ,Rogier W Sanders ,Kristina De Paris ,Sallie R Permar

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques

针对种系的 SOSIP 三聚体免疫可在幼年恒河猴中诱发针对前体 CD4 结合位点的广谱中和抗体

Ashley N Nelson, Xiaoying Shen, Sravani Vekatayogi, Shiyu Zhang, Gabriel Ozorowski, Maria Dennis, Leigh M Sewall, Emma Milligan, Dominique Davis, Kaitlyn A Cross, Yue Chen, Jelle van Schooten, Joshua Eudailey, John Isaac, Saad Memon, Carolyn Weinbaum, Sherry Stanfield-Oakley, Alliyah Byrd, Suni Chut

Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation

自组装肽纳米纤维 HIV 疫苗可引发强大的疫苗诱导抗体功能并调节 Fc 糖基化

Jui-Lin Chen, Chelsea N Fries, Stella J Berendam, Nicole S Rodgers, Emily F Roe, Yaoying Wu, Shuk Hang Li, Rishabh Jain, Brian Watts, Joshua Eudailey, Richard Barfield, Cliburn Chan, M Anthony Moody, Kevin O Saunders, Justin Pollara, Sallie R Permar, Joel H Collier, Genevieve G Fouda

Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses

母体广泛且强大的抗体反应环境下的 HIV-1 垂直传播

Joshua J Tu, Amit Kumar, Elena E Giorgi, Joshua Eudailey, Celia C LaBranche, David R Martinez, Genevieve G Fouda, Yvetane Moreau, Allison Thomas, David Montefiori, Feng Gao, Manish Sagar, Sallie R Permar

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

HIV包膜抗原在肽纳米纤维上的价态调节抗体强度和结合广度

Chelsea N Fries # ,Jui-Lin Chen # ,Maria L Dennis ,Nicole L Votaw ,Joshua Eudailey ,Brian E Watts ,Kelly M Hainline ,Derek W Cain ,Richard Barfield ,Cliburn Chan ,M Anthony Moody ,Barton F Haynes ,Kevin O Saunders ,Sallie R Permar ,Genevieve G Fouda ,Joel H Collier

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

母体广谱中和抗体可筛选出对中和抗体具有抵抗力的、可通过婴儿传播/创始的 HIV 变异株

David R Martinez # ,Joshua J Tu # ,Amit Kumar ,Jesse F Mangold ,Riley J Mangan ,Ria Goswami ,Elena E Giorgi ,Juilin Chen ,Michael Mengual ,Ayooluwa O Douglas ,Holly Heimsath ,Kevin O Saunders ,Nathan I Nicely ,Joshua Eudailey ,Giovanna Hernandez ,Papa Kwadwo Morgan-Asiedu ,Kevin Wiehe ,Barton F Haynes ,M Anthony Moody ,Celia LaBranche ,David C Montefiori ,Feng Gao # ,Sallie R Permar #

HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy

新生儿恒河猴接种疫苗后诱发的 HIV 包膜特异性 IgG 抗体持续存在,并且可以通过婴儿期的后期加强免疫得到增强

Alan D Curtis 2nd, Maria Dennis, Joshua Eudailey, Korey L Walter, Kenneth Cronin, S Munir Alam, Neelima Choudhary, Ryan H Tuck, Michael Hudgens, Pamela A Kozlowski, Justin Pollara, Guido Ferrari, Koen K A Van Rompay, Sallie Permar, Kristina De Paris

Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques

CH31 广谱中和抗体的共同给药不会影响婴儿恒河猴疫苗诱导的抗 HIV-1 包膜抗体反应的发展

Maria Dennis, Joshua Eudailey, Justin Pollara, Arthur S McMillan, Kenneth D Cronin, Pooja T Saha, Alan D Curtis, Michael G Hudgens, Genevieve G Fouda, Guido Ferrari, Munir Alam, Koen K A Van Rompay, Kristina De Paris, Sallie Permar, Xiaoying Shen

Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization

全身施用 HIV-1 广谱中和二聚体 IgA 可产生粘膜分泌型 IgA 和病毒中和

Genevieve G Fouda, Joshua Eudailey #, Erika L Kunz #, Joshua D Amos, Brooke E Liebl, Jonathan Himes, Felix Boakye-Agyeman, Krista Beck, Anthony J Michaels, Michael Cohen-Wolkowiez, Barton F Haynes, Keith A Reimann, Sallie R Permar

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

MPER 定向 HIV-1 中和抗体 10E8 的开发途径

Cinque Soto, Gilad Ofek, M Gordon Joyce, Baoshan Zhang, Krisha McKee, Nancy S Longo, Yongping Yang, Jinghe Huang, Robert Parks, Joshua Eudailey, Krissey E Lloyd, S Munir Alam, Barton F Haynes; NISC Comparative Sequencing Program; James C Mullikin, Mark Connors, John R Mascola, Lawrence Shapiro, Pete