日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions.

酪氨酸激酶中磷酸酪氨酸识别的主要分子决定因素的结构鉴定揭示了其促肿瘤和抑肿瘤功能

Cheng Nuo, Millán-Barea Luis R, Creixell Marc, Barr Alexis R, Kong Yi Wen, Joughin Brian A, Lopez Cécile K, Lengefeld Jette, Clarke James, Liu Chuan, Sriram Ganapathy, González-Robles Tania J, van de Kooij Bert, Savickas Simonas, Schoof Erwin M, Johnson Jared L, Bakal Chris, Cantley Lewis C, Chiarle Roberto, Pritchard Justin, Hubbard Stevan, Huntly Brian J P, Hemann Michael, Creixell Pau, Yaffe Michael B

An in vitro intestinal model captures immunomodulatory properties of the microbiota in inflammation

体外肠道模型能够模拟炎症中肠道菌群的免疫调节特性。

Lock, Jaclyn Y; Caboni, Mariaelena; Strandwitz, Philip; Morrissette, Madeleine; DiBona, Kevin; Joughin, Brian A; Lewis, Kim; Carrier, Rebecca L

Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion

损伤后凝血功能障碍的蛋白质组学研究揭示了使用实验室评估来定义创伤性凝血功能障碍以预测大量输血的局限性

Moore, Hunter B; Neal, Matthew D; Bertolet, Marnie; Joughin, Brian A; Yaffe, Michael B; Barrett, Christopher D; Bird, Molly A; Tracy, Russell P; Moore, Ernest E; Sperry, Jason L; Zuckerbraun, Brian S; Park, Myung S; Cohen, Mitchell J; Wisniewski, Stephen R; Morrissey, James H

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

在自闭症小鼠模型中,Shank3基因突变导致S-亚硝基蛋白质组发生改变,并影响参与囊泡释放和突触功能的关键蛋白。

Amal, Haitham; Barak, Boaz; Bhat, Vadiraja; Gong, Guanyu; Joughin, Brian A; Wang, Xin; Wishnok, John S; Feng, Guoping; Tannenbaum, Steven R

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

转录因子和通路分析工具在单细胞RNA测序数据上的稳健性和适用性

Holland, Christian H; Tanevski, Jovan; Perales-Patón, Javier; Gleixner, Jan; Kumar, Manu P; Mereu, Elisabetta; Joughin, Brian A; Stegle, Oliver; Lauffenburger, Douglas A; Heyn, Holger; Szalai, Bence; Saez-Rodriguez, Julio

Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper.

多重血浆免疫介质特征可区分脓毒症和非感染性全身炎症反应综合征:美国外科协会 2020 年会论文

Cahill Laura A, Joughin Brian A, Kwon Woon Yong, Itagaki Kiyoshi, Kirk Charlotte H, Shapiro Nathan I, Otterbein Leo E, Yaffe Michael B, Lederer James A, Hauser Carl J

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

肿瘤基质边界的酸化驱动与侵袭性表型相关的转录组改变

Rohani Nazanin, Hao Liangliang, Alexis Maria S, Joughin Brian A, Krismer Konstantin, Moufarrej Mira N, Soltis Anthony R, Lauffenburger Douglas A, Yaffe Michael B, Burge Christopher B, Bhatia Sangeeta N, Gertler Frank B

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

在异步细胞周期进程中的有丝分裂过程中,活性氧和氧化应激水平升高,并且有丝分裂停滞会加剧这种情况

Patterson Jesse C, Joughin Brian A, van de Kooij Bert, Lim Daniel C, Lauffenburger Douglas A, Yaffe Michael B

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme

多条通路中的DNA修复能力可预测多形性胶质母细胞瘤的化疗耐药性

Nagel, Zachary D; Kitange, Gaspar J; Gupta, Shiv K; Joughin, Brian A; Chaim, Isaac A; Mazzucato, Patrizia; Lauffenburger, Douglas A; Sarkaria, Jann N; Samson, Leona D

Systems Approaches to Cancer Biology

癌症生物学的系统方法

Archer, Tenley C; Fertig, Elana J; Gosline, Sara J C; Hafner, Marc; Hughes, Shannon K; Joughin, Brian A; Meyer, Aaron S; Piccolo, Stephen R; Shajahan-Haq, Ayesha N