日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion

高分辨率CTCF足迹分析揭示染色质状态对黏连蛋白挤出的影响

Sept, Corriene E; Tak, Y Esther; Goel, Viraat; Bhakta, Mital S; Cerda-Smith, Christian G; Hutchinson, Haley M; Blanchette, Marco; Eyler, Christine E; Johnstone, Sarah E; Joung, J Keith; Hansen, Anders S; Aryee, Martin J

The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis

E3连接酶HECTD4调控COX-2依赖性肿瘤进展和转移

Vuille, Joanna A; Tanriover, Cem; Antmen, Ezgi; Micalizzi, Douglas S; Ebright, Richard Y; Animesh, Sambhavi; Morris, Robert; Hajizadeh, Soroush; Nicholson, Zachary J; Russell, Hunter C; Zaniewski, Eric F; Wittner, Ben S; Wesley, Ben K; Kwak, Ji Eun; Grünewald, Julian; Szalay, Regan N; Fox, Douglas B; Yang, Min; Joung, J Keith; Gulhan, Doga C; Elia, Andrew E H; Haas, Wilhelm; Oh, Eugene; Maheswaran, Shyamala; Haber, Daniel A

Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

通过减少错误折叠的pegRNA相互作用来增强CRISPR启动编辑。

Zhang, Weiting; Petri, Karl; Ma, Junyan; Lee, Hyunho; Tsai, Chia-Lun; Joung, J Keith; Yeh, Jing-Ruey Joanna

MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells

MOSAIC技术能够对人类细胞中的基因进行原位饱和诱变,并优化CRISPR引导RNA编辑。

Hsu, Jonathan Y; Lam, Kin Chung; Shih, Justine; Pinello, Luca; Joung, J Keith

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

神经母细胞瘤的遗传易感性源于一种促进肾上腺素能细胞状态的调控多态性。

Weichert-Leahey, Nina; Shi, Hui; Tao, Ting; Oldridge, Derek A; Durbin, Adam D; Abraham, Brian J; Zimmerman, Mark W; Zhu, Shizhen; Wood, Andrew C; Reyon, Deepak; Joung, J Keith; Young, Richard A; Diskin, Sharon J; Maris, John M; Look, A Thomas

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

无需体外培养的基因编辑可避免对人类造血干细胞造成基因毒性。

Zeng, Jing; Nguyen, My Anh; Liu, Pengpeng; Ferreira da Silva, Lucas; Lin, Linda Y; Justus, David G; Petri, Karl; Clement, Kendell; Porter, Shaina N; Verma, Archana; Neri, Nola R; Rosanwo, Tolulope; Ciuculescu, Marioara-Felicia; Abriss, Daniela; Mintzer, Esther; Maitland, Stacy A; Demirci, Selami; Tisdale, John F; Williams, David A; Zhu, Lihua Julie; Pruett-Miller, Shondra M; Pinello, Luca; Joung, J Keith; Pattanayak, Vikram; Manis, John P; Armant, Myriam; Pellin, Danilo; Brendel, Christian; Wolfe, Scot A; Bauer, Daniel E

High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion dynamics

高分辨率CTCF足迹分析揭示染色质状态对黏连蛋白挤出动力学的影响

Sept, Corriene E; Tak, Y Esther; Cerda-Smith, Christian G; Hutchinson, Haley M; Goel, Viraat; Blanchette, Marco; Bhakta, Mital S; Hansen, Anders S; Joung, J Keith; Johnstone, Sarah; Eyler, Christine E; Aryee, Martin J

Multidimensional control of therapeutic human cell function with synthetic gene circuits

利用合成基因回路对治疗性人类细胞功能进行多维度控制

Li, Hui-Shan; Israni, Divya V; Gagnon, Keith A; Gan, Kok Ann; Raymond, Michael H; Sander, Jeffry D; Roybal, Kole T; Joung, J Keith; Wong, Wilson W; Khalil, Ahmad S

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

PrimeDesign 软件用于快速简化设计引物编辑引导 RNA

Hsu, Jonathan Y; Grünewald, Julian; Szalay, Regan; Shih, Justine; Anzalone, Andrew V; Lam, Kin Chung; Shen, Max W; Petri, Karl; Liu, David R; Joung, J Keith; Pinello, Luca

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

对基于 CRISPR 的基因驱动在人类疟蚊中的脱靶效应进行分析

Garrood, William T; Kranjc, Nace; Petri, Karl; Kim, Daniel Y; Guo, Jimmy A; Hammond, Andrew M; Morianou, Ioanna; Pattanayak, Vikram; Joung, J Keith; Crisanti, Andrea; Simoni, Alekos