N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors
N-烷基和N-芳基氨基吡唑螺环氨基甲酸酯:一种用于筛选口服生物利用度高的血浆激肽释放酶抑制剂的双管齐下先导化合物优化策略
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.6c00066
Merchant, Rohan R; Chernyak, Natalia; Lopez, Jovan A; Sharp, Phillip P; Mandal, Mihir; He, Jiafang; Hruza, Alan; Rearden, Paul; Tatosian, Daniel A; Esmay, Joel; Yang, Song; Cheng, Alan C; Ellsworth, Ken; Ogawa, Aimie; Piou, Tiffany; Fier, Patrick; Hicks, Jacqueline; Sinz, Christopher; Ogawa, Anthony K