日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease

含有噻唑-4-基丙氨酸的肽醛是SARS-CoV-2主蛋白酶的强效体外抑制剂

Feys, Jenson R; Edwards, Kyle; Joyce, Michael A; Saffran, Holly A; Shields, Justin A; Garcia, Kassandra; Tyrrell, D Lorne; Fischer, Conrad

Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters

两种DNA疫苗可保护叙利亚仓鼠免受SARS-CoV-2引起的严重疾病和病理影响

Babuadze, George Giorgi; Fausther-Bovendo, Hugues; deLaVega, Marc-Antoine; Lillie, Brandon; Naghibosadat, Maedeh; Shahhosseini, Nariman; Joyce, Michael A; Saffran, Holly A; Lorne Tyrrell, D; Falzarano, Darryl; Senthilkumaran, Chandrika; Christie-Holmes, Natasha; Ahn, Steven; Gray-Owen, Scott D; Banerjee, Arinjay; Mubareka, Samira; Mossman, Karen; Dupont, Chanel; Pedersen, Jannie; Lafrance, Mark-Alexandre; Kobinger, Gary P; Kozak, Robert

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

作者更正:猫冠状病毒药物抑制SARS-CoV-2的主要蛋白酶并阻断病毒复制。

Vuong, Wayne; Khan, Muhammad Bashir; Fischer, Conrad; Arutyunova, Elena; Lamer, Tess; Shields, Justin; Saffran, Holly A; McKay, Ryan T; van Belkum, Marco J; Joyce, Michael A; Young, Howard S; Tyrrell, D Lorne; Vederas, John C; Lemieux, M Joanne

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

丙型肝炎病毒诱导的膜状网络及其相关的核转运机制限制了模式识别受体与病毒复制位点的接触。

Neufeldt, Christopher J; Joyce, Michael A; Van Buuren, Nicholas; Levin, Aviad; Kirkegaard, Karla; Gale, Michael Jr; Tyrrell, D Lorne J; Wozniak, Richard W

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza

IL-28B是B细胞和T细胞对流感疫苗反应的关键调节因子

Egli, Adrian; Santer, Deanna M; O'Shea, Daire; Barakat, Khaled; Syedbasha, Mohammedyaseen; Vollmer, Madeleine; Baluch, Aliyah; Bhat, Rakesh; Groenendyk, Jody; Joyce, Michael A; Lisboa, Luiz F; Thomas, Brad S; Battegay, Manuel; Khanna, Nina; Mueller, Thomas; Tyrrell, D Lorne J; Houghton, Michael; Humar, Atul; Kumar, Deepali

Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication.

丙型肝炎病毒诱导的细胞质细胞器利用核转运机制建立有利于病毒复制的环境

Neufeldt Christopher J, Joyce Michael A, Levin Aviad, Steenbergen Rineke H, Pang Daniel, Shields Justin, Tyrrell D Lorne J, Wozniak Richard W

Biochemical and structural characterization of the GTP-preferring succinyl-CoA synthetase from Thermus aquaticus

水生栖热菌GTP优先琥珀酰辅酶A合成酶的生化和结构表征

Joyce, Michael A; Hayakawa, Koto; Wolodko, William T; Fraser, Marie E

Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication

基于活性的蛋白质谱分析鉴定出一种宿主酶——羧酸酯酶1,该酶在丙型肝炎病毒复制过程中具有差异活性。

Blais, David R; Lyn, Rodney K; Joyce, Michael A; Rouleau, Yanouchka; Steenbergen, Rineke; Barsby, Nicola; Zhu, Lin-Fu; Pegoraro, Adrian F; Stolow, Albert; Tyrrell, David L; Pezacki, John Paul

HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice

HCV可诱导SCID/Alb-uPA小鼠发生氧化应激和内质网应激,并使感染细胞对凋亡更加敏感。

Joyce, Michael A; Walters, Kathie-Anne; Lamb, Sue-Ellen; Yeh, Mathew M; Zhu, Lin-Fu; Kneteman, Norman; Doyle, Jason S; Katze, Michael G; Tyrrell, D Lorne

Cloning, expression, purification, crystallization and preliminary X-ray analysis of Thermus aquaticus succinyl-CoA synthetase

水生栖热菌琥珀酰辅酶A合成酶的克隆、表达、纯化、结晶及初步X射线分析

Joyce, Michael A; Brownie, Edward R; Hayakawa, Koto; Fraser, Marie E