日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C

STING 信号的强直启动-增强可介导 C 型尼曼匹克病

Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu, Joyce J Repa, Nan Yan

Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin

缺乏胆固醇酯化酶 SOAT2 的 Npc1-/-nih 小鼠对 2-羟丙基-β-环糊精急性治疗的代谢反应描述

Charina M Ramirez, Anna M Taylor, Adam M Lopez, Joyce J Repa, Stephen D Turley

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

ACSS2 通过选择性调控参与脂质代谢的基因来促进全身脂肪储存和利用

Zhiguang Huang, Menglu Zhang, Abigail A Plec, Sandi Jo Estill, Ling Cai, Joyce J Repa, Steven L McKnight, Benjamin P Tu

Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat

使用组蛋白去乙酰化酶抑制剂伏立诺他治疗后,尼曼匹克 C 型疾病 Npc1nmf164 小鼠模型的肝稳态恢复正常

Andrew B Munkacsi, Natalie Hammond, Remy T Schneider, Dinindu S Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J Bloor, Daniel S Ory, Robert A Maue, Fannie W Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J Repa, Henry N Ginsberg, Yiannis A Ioannou, Stephen L Sturley

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Xbp1s/GalE 轴将 ER 应激与餐后肝脏代谢联系起来

Yingfeng Deng, Zhao V Wang, Caroline Tao, Ningguo Gao, William L Holland, Anwarul Ferdous, Joyce J Repa, Guosheng Liang, Jin Ye, Mark A Lehrman, Joseph A Hill, Jay D Horton, Philipp E Scherer

Carboxylesterases are uniquely expressed among tissues and regulated by nuclear hormone receptors in the mouse

羧酸酯酶在组织中具有独特的表达,并受小鼠核激素受体的调控

Ryan D Jones, Anna M Taylor, Ernest Y Tong, Joyce J Repa

Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells

生长素释放肽直接刺激胰腺 α 细胞分泌胰高血糖素

Jen-Chieh Chuang, Ichiro Sakata, Daisuke Kohno, Mario Perello, Sherri Osborne-Lawrence, Joyce J Repa, Jeffrey M Zigman

Chronic social defeat stress disrupts regulation of lipid synthesis

慢性社交失败压力会破坏脂质合成的调节

Jen-Chieh Chuang, Huxing Cui, Brittany L Mason, Melissa Mahgoub, Angie L Bookout, Hana G Yu, Mario Perello, Joel K Elmquist, Joyce J Repa, Jeffrey M Zigman, Michael Lutter

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

肝脏 X 受体激动剂通过激活补充途径和甘油脂/游离脂肪酸循环增强人类胰岛功能

Takeshi Ogihara, Jen-Chieh Chuang, George L Vestermark, James C Garmey, Robert J Ketchum, Xiaolun Huang, Kenneth L Brayman, Michael O Thorner, Joyce J Repa, Raghavendra G Mirmira, Carmella Evans-Molina

Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1

多种机制限制了 ACAT2 和 ABCA1 缺陷小鼠小肠中未酯化胆固醇的积累

Stephen D Turley, Mark A Valasek, Joyce J Repa, John M Dietschy