日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide

使用针对 CAG 重复序列的反义寡核苷酸抑制 SCA3 和 SCA1 小鼠中的突变蛋白表达

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2019.07.004
Eleni Kourkouta, Rudie Weij, Anchel González-Barriga, Melissa Mulder, Ruurd Verheul, Sieto Bosgra, Bas Groenendaal, Jukka Puoliväli, Jussi Toivanen, Judith C T van Deutekom, Nicole A Datson
发表日期：2019
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Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro

体外肌母细胞和分化肌管细胞中反义寡核苷酸在非辅助摄取后的细胞内分布和核活性

期刊:Nucleic Acid Therapeutics
影响因子:4.7
doi:10.1089/nat.2016.0641
González-Barriga, Anchel; Nillessen, Bram; Kranzen, Julia; van Kessel, Ingeborg D G; Croes, Huib J E; Aguilera, Begoña; de Visser, Peter C; Datson, Nicole A; Mulders, Susan A M; van Deutekom, Judith C T; Wieringa, Bé; Wansink, Derick G
细胞生物学
发表日期：2017
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The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain

亨廷顿基因中 CAG 重复扩增是整个亨廷顿氏病小鼠大脑中治疗性 RNA 调节的靶点

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0171127
Nicole A Datson, Anchel González-Barriga, Eleni Kourkouta, Rudie Weij, Jeroen van de Giessen, Susan Mulders, Outi Kontkanen, Taneli Heikkinen, Kimmo Lehtimäki, Judith C T van Deutekom
信号转导
Mouse
发表日期：2017
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Digital Droplet PCR for the Absolute Quantification of Exon Skipping Induced by Antisense Oligonucleotides in (Pre-)Clinical Development for Duchenne Muscular Dystrophy

数字液滴PCR技术用于绝对定量杜氏肌营养不良症（临床前）开发中反义寡核苷酸诱导的外显子跳跃

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0162467
Verheul, Ruurd C; van Deutekom, Judith C T; Datson, Nicole A
发表日期：2016
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Cell membrane integrity in myotonic dystrophy type 1: implications for therapy

型强直性肌营养不良症的细胞膜完整性：对治疗的意义

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0121556
Anchel González-Barriga, Julia Kranzen, Huib J E Croes, Suzanne Bijl, Walther J A A van den Broek, Ingeborg D G van Kessel, Baziel G M van Engelen, Judith C T van Deutekom, Bé Wieringa, Susan A M Mulders, Derick G Wansink
细胞生物学
其它细胞
发表日期：2015
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The Dynamics of Compound, Transcript, and Protein Effects After Treatment With 2OMePS Antisense Oligonucleotides in mdx Mice

2OMePS 反义寡核苷酸治疗 mdx 小鼠后化合物、转录本和蛋白质效应的动态

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1038/mtna.2014.1
Ingrid E C Verhaart, Laura van Vliet-van den Dool, Jessica A Sipkens, Sjef J de Kimpe, Ingrid G M Kolfschoten, Judith C T van Deutekom, Lia Liefaard, Jim E Ridings, Steve R Hood, Annemieke Aartsma-Rus
信号转导
发表日期：2014
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Prednisolone treatment does not interfere with 2'-O-methyl phosphorothioate antisense-mediated exon skipping in Duchenne muscular dystrophy

泼尼松龙治疗不会干扰杜氏肌营养不良症中 2'-O-甲基硫代磷酸酯反义介导的外显子跳跃

期刊:Human Gene Therapy
影响因子:3.9
doi:10.1089/hum.2011.127
Ingrid E C Verhaart, Hans Heemskerk, Tatyana G Karnaoukh, Ingrid G M Kolfschoten, Anne Vroon, Gert-Jan B van Ommen, Judith C T van Deutekom, Annemieke Aartsma-Rus
信号转导
发表日期：2012
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Targeting several CAG expansion diseases by a single antisense oligonucleotide.

利用单个反义寡核苷酸靶向治疗多种 CAG 扩增疾病

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0024308
Evers Melvin M, Pepers Barry A, van Deutekom Judith C T, Mulders Susan A M, den Dunnen Johan T, Aartsma-Rus Annemieke, van Ommen Gert-Jan B, van Roon-Mom Willeke M C
其它
发表日期：2011
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Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model

在 mdx 小鼠模型中对 2'-O-甲基硫代磷酸酯 RNA 反义寡核苷酸进行临床前药代动力学和药效学研究

期刊:Molecular Therapy
影响因子:12
doi:10.1038/mt.2010.72
Heemskerk, Hans; de Winter, Christa; van Kuik, Petra; Heuvelmans, Niki; Sabatelli, Patrizia; Rimessi, Paola; Braghetta, Paola; van Ommen, Gert-Jan B; de Kimpe, Sjef; Ferlini, Alessandra; Aartsma-Rus, Annemieke; van Deutekom, Judith C T
发表日期：2010
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Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms

反义寡核苷酸设计指南及剪接调控机制解析

期刊:Molecular Therapy
影响因子:12
doi:10.1038/mt.2008.205
Aartsma-Rus, Annemieke; van Vliet, Laura; Hirschi, Marscha; Janson, Anneke A M; Heemskerk, Hans; de Winter, Christa L; de Kimpe, Sjef; van Deutekom, Judith C T; 't Hoen, Peter A C; van Ommen, Gert-Jan B
信号转导
发表日期：2009
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