Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia
ATM介导的CD98HC磷酸化缺失会损害反向转运蛋白的运输,并导致共济失调毛细血管扩张症中的谷氨酸毒性。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60304-4
Romero, July Carolina; Tonapi, Sonal S; Parihar, Manish; Loranc, Eva; Miller, Henry E; Lawrence, Liesl A; Bassani, Nicklas; Robledo, Daniel G; Cao, Lin; Nie, Jia; Kanda, Kairi; Stoja, Aiola; Garcia, Natalia; Gorthi, Aparna; Stoveken, Brian J; Fan, Teresa W-M; Cassel, Teresa A; Zha, Shan; Lechleiter, James D; Musi, Nicolas; Dong, Lily Q; Lane, Andrew N; Bishop, Alexander J R