文献库，生知库 | 链接生命科学的每一步

日期影响因子

An examination of the mechanisms driving the therapeutic effects of an AAV expressing a soluble variant of VEGF receptor-1

研究驱动表达 VEGF 受体 1 可溶性变体的 AAV 治疗效果的机制

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0305466

Seo Yun Moon, Hee Jong Kim, Jin Kwon Kim, Jin Kim, Jun-Sub Choi, So-Yoon Won, Keerang Park, Steven Hyun Seung Lee

发表日期：2024

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mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy

mTOR 下调通过缺氧视网膜病变中的 CCL3-CCR5 轴促进抗炎反应

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2024.101404

Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

发表日期：2024

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scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma

scAAV2 介导的硫氧还蛋白 2 和 C3 转移酶表达可防止青光眼小鼠模型中的视网膜神经节细胞死亡并降低眼压

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms242216253

Hee Jong Kim, Seho Cha, Jun-Sub Choi, Joo Yong Lee, Ko Eun Kim, Jin Kwon Kim, Jin Kim, Seo Yun Moon, Steven Hyun Seung Lee, Keerang Park, So-Yoon Won

细胞生物学

发表日期：2023

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mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy

mTOR 抑制作为糖尿病视网膜病变的新型基因治疗策略

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0269951

Steven Hyun Seung Lee, Joo Yong Lee, Jun-Sub Choi, Hee Jong Kim, Jin Kim, Seho Cha, Kyoung Jin Lee, Ha-Na Woo, Keerang Park, Heuiran Lee

发表日期：2022

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AAV expressing an mTOR-inhibiting siRNA exhibits therapeutic potential in retinal vascular disorders by preserving endothelial integrity

表达 mTOR 抑制 siRNA 的 AAV 通过保持内皮完整性在视网膜血管疾病中表现出治疗潜力

期刊:FEBS Open Bio

影响因子:2.8

doi:10.1002/2211-5463.13281

Seho Cha, Won-Il Seo, Ha-Na Woo, Hee Jong Kim, Steven Hyun Seung Lee, Jin Kim, Jun-Sub Choi, Keerang Park, Joo Yong Lee, Beom Jun Lee, Heuiran Lee

发表日期：2022

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Inhibition of mTOR via an AAV-Delivered shRNA Tested in a Rat OIR Model as a Potential Antiangiogenic Gene Therapy

在大鼠 OIR 模型中测试通过 AAV 递送的 shRNA 抑制 mTOR 作为潜在的抗血管生成基因疗法

期刊:Investigative Ophthalmology & Visual Science

doi:10.1167/iovs.61.2.45

Steven Hyun Seung Lee, HeeSoon Chang, Ji Hyun Kim, Hee Jong Kim, Jun-Sub Choi, Sunho Chung, Ha-Na Woo, Kyoung Jin Lee, Keerang Park, Joo Yong Lee, Heuiran Lee

发表日期：2020

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Effects of Stuffer DNA on the Suppression of Choroidal Neovascularization by a rAAV Expressing a mTOR-Inhibiting shRNA

填充 DNA 对表达 mTOR 抑制 shRNA 的 rAAV 抑制脉络膜新生血管的影响

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2019.06.004

Steven Hyun Seung Lee, HeeSoon Chang, Hee Jong Kim, Jun-Sub Choi, Jin Kim, Ji Hyun Kim, Ha-Na Woo, Seung Kwan Nah, Sang Joon Jung, Joo Yong Lee, Keerang Park, Tae Kwann Park, Heuiran Lee

发表日期：2019

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Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization

玻璃体内注射表达可溶性 VEGF 受体 1 变体的 AAV 可诱导抗 VEGF 活性并抑制脉络膜新生血管

期刊:Investigative Ophthalmology & Visual Science

doi:10.1167/iovs.18-24926

Steven Hyun Seung Lee, Hee Jong Kim, Oh Kyu Shin, Jun-Sub Choi, Jin Kim, Young-Hwa Cho, Joohun Ha, Tae Kwann Park, Joo Yong Lee, Keerang Park, Heuiran Lee

发表日期：2018

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AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration

AIF 独立的 parthanatos 在干性年龄相关性黄斑变性的发病机制中的作用

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/cddis.2016.437

Ki-Hong Jang, Yun-Ju Do, Dongwon Son, Eunji Son, Jun-Sub Choi, Eunhee Kim

发表日期：2017

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Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization

腺相关病毒载体介导的短发夹 RNA 抑制 mTOR 可抑制激光诱导的脉络膜新生血管

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.5

doi:10.1016/j.omtn.2017.05.012

Tae Kwann Park, Si Hyung Lee, Jun Sub Choi, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Heuiran Lee, Steven Hyun Seung Lee, Keerang Park

发表日期：2017

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