日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From Pharmacophore to Warhead: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors

从药效团到活性位点:靶向 NAD(+) 的三唑类化合物作为基于机制的 Sirtuin 抑制剂

Friedrich, Florian; Meleshin, Marat; Papenkordt, Niklas; Gaitzsch, Lena; Prucker, Isabel; Borso, Marco; Ruprecht, Jan; Vorreiter, Christopher; Rast, Sabrina; Zhang, Lin; Schiedel, Matthias; Sippl, Wolfgang; Imhof, Axel; Jessen, Henning J; Einsle, Oliver; Schutkowski, Mike; Jung, Manfred

Molecular determinants for recognition of serotonylated chromatin

识别血清素化染色质的分子决定因素

Pulido-Cortés, Laura; Gielingh, Hajo; Thijssen, Vito; Liu, Minglong; Yoshisada, Ryoji; Romão Soares, Leonardo; Nizamuddin, Sheikh; Friedrich, Florian; Greschik, Holger; Peng, Ling; Vargas Honorato, Rodrigo; Jung, Manfred; Bonvin, Alexandre M J J; Biniossek, Martin L; Schüle, Roland; Jongkees, Seino; van Ingen, Hugo; Timmers, H Th Marc

Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions.

高效结晶 Apo Sirt2 用于小分子浸泡和配体相互作用的结构分析

Friedrich Florian, Schiedel Matthias, Swyter Sören, Zhang Lin, Sippl Wolfgang, Schutkowski Mike, Einsle Oliver, Jung Manfred

Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity.

基于结构的KMT9抑制剂前药设计及其细胞活性

Wang Sheng, Barthes Nicolas P F, Urban Sylvia, Hazai Viktor I, Klein Sebastian O, Pappert Tabea, Kümmel Paul, Heller Nicolas, Bacher Johannes, Staudt Maximilian, Ruprecht Jan, Peng Ling, Sum Manuela, Berlin Christopher, Sarraf Daad, Regenass Pierre, Warstat Robin, Walz Johannes, Mishra Pankaj, Zhang Lin, Einsle Oliver, Günther Stefan, Breit Bernhard, Metzger Eric, Jung Manfred, Schüle Roland

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Schistosoma mansoni Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages.

苯并二氮杂黄素 Sirtuin 抑制剂抑制曼氏血吸虫 Sirt2,导致血吸虫幼虫和成虫阶段的表型变化和致死性。

Gimmelli Roberto, Papoff Giuliana, Fabbrizi Emanuele, Guida Michela, Lalli Cristiana, Saccoccia Fulvio, Häberli Cécile, Keiser Jennifer, Monaldi Daria, Jung Manfred, Romier Christophe, Rotili Dante, Mai Antonello, Ruberti Giovina

Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD(+) co-factor binding.

定制的 SirReal 型抑制剂通过配体稳定和破坏 NAD(+) 辅因子结合来增强 SIRT2 抑制作用

Wirawan Ricky, Frei Matthias, Heider Anna, Papenkordt Niklas, Friedrich Florian, Wein Thomas, Jung Manfred, Groll Michael, Huber Eva M, Bracher Franz

The bioactivity of atraric acid as an inducer of cellular senescence in prostate cancer cells is retained by lipophilic derivatives

阿特拉酸作为前列腺癌细胞衰老诱导剂的生物活性可被亲脂性衍生物保留。

Baniahmad, Adina Asara; Atri Roozbahani, Golnaz; Jung, Manfred; Baniahmad, Aria

Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis

广谱多聚磷酸激酶2-II酶的结构解析及其在嘧啶核苷二磷酸合成中的应用

Kuge, Marco; Keppler, Michael; Friedrich, Florian; Saleem-Batcha, Raspudin; Winter, Juliana; Prucker, Isabel; Germer, Philipp; Gerhardt, Stefan; Einsle, Oliver; Jung, Manfred; Jessen, Henning J; Andexer, Jennifer N

Sensitization of Non-M3 Acute Myeloid Leukemia Blasts to All-Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study

LSD1抑制剂反式环丙胺增强非M3型急性髓系白血病原始细胞对全反式维甲酸的敏感性:TRANSATRA I期研究

Kruszewski, Michael; Schmoor, Claudia; Berg, Tobias; Rehman, Usama-Ur; Schittenhelm, Marcus; Götze, Katharina; Kündgen, Andrea; Pabst, Caroline; Ma, Tobias; Frey, Anna; Stomper, Julia; Pfeifer, Dietmar; Metzger, Eric; Jung, Johannes; Moschallski, Kevin; Thomas, Johanna; Bug, Gesine; Duyster, Justus; Jung, Manfred; Schüle, Roland; Wäsch, Ralph; Grishina, Olga; Lübbert, Michael

Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors.

芳香族氨基酸羟化酶是组蛋白去乙酰化酶抑制剂的脱靶靶点

Baumann Anne, Papenkordt Niklas, Robaa Dina, Szigetvari Peter D, Vogelmann Anja, Bracher Franz, Sippl Wolfgang, Jung Manfred, Haavik Jan