Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis.
支链α-酮酸通过重新激活LDHA-乳酸轴,损害糖尿病状态下胰腺β细胞中葡萄糖刺激的胰岛素分泌。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-70004-2
Lin Huige, Ho Melody Yuen Man, Wang Baomin, Mansoori Shama, Yang Yumei, Wang Wen, So Pui Kin, Xu Aimin, Yang Shilun, Chang Junlei, Man Ada Man Hau, Piao Hailong, Gao Chen, Siu Parco Ming Fai, Li Xiaomu, Cheng Kenneth King Yip